Genomics and Applied Biology 2018, Vol.9, No.10, 62-71
69
7 Expectation
With more and more researchers paying attention to lncRNA and the continuous development of sequencing
technology, more and more lncRNA have been identified, of which some play a very wide role in the organism.
lncRNA is also very important in the generation and development of cancer, which shows a variety of biological
functions in cancer, such as epigenetic regulation, inhibition or activation of gene expression. It has been fully
recognized that lncRNA plays an important role in organisms. However, compared with other researches,
researches on lncRNA are still at the beginning stage so far, because there are still many problems that need to be
solved urgently about lncRNA.
There is still no accurate method for the identification of lncRNA. Some transcripts have open reading frames but
cannot encode proteins, while some lncRNA have the function of translating small peptides because of the
definition of lncRNA. In these two cases, if we take whether proteins can be encoded as the basis to determine
whether transcripts are lncRNA, errors will be caused.
Due to the complexity and diversity of lncRNA function and structure, the identification of lncRNA should not
only be through several existing methods. We need to develop more effective methods to identify lncRNA and
conduct more extensive and systematic studies.
Authors’ contributions
WGF carried out the analysis and drafted the manuscript. THB supervised the study and critically revised the manuscript. All authors
read and approved the final manuscript.
Acknowledgements
This research is supported by “Seven Crops” key projects of National Key Research and Development Program (2016YFD0100305),
Fujian ‘Hundred Talents’ Program and National Natural Science Foundation for Young Scholars.
References
Amaral P.P., Clark M.B., Gascoigne D.K., Dinger M.E., and Mattick J.S., 2011, lncRNAdb: a reference database for long noncoding RNAs, Nucleic Acids
Research, 39(suppl_1): D146-D151
Burns A.I.S., 2009, Alzheimer’s disease, BMJ: British Medical Journal, 338(7692): 467-471
Chen D.L., Chen L.Z., Lu Y.X., Zhang D.S., Zeng Z.L., Pan Z.Z., Huang P., Wang F.H., Li Y.H., Ju H.Q., and Xu R.H., 2017, Long noncoding RNA XIST
expedites metastasis and modulates epithelial-mesenchymal transition in colorectal cancer, Cell Death and Disease, 8(8): e3011
PMid:28837144 PMCid:PMC5596599
Chen G., Wang Z.Y., Wang D.Q., Qiu C.X., Liu M.X., Chen X., Zhang Q.P., Yan G.Y., and Cui Q.H., 2012, LncRNA Disease: a database for long-non-coding
RNA-associated diseases, Nucleic Acids Research, 41(D1): D983-D986
PMid:23175614 PMCid:PMC3531173
Ding J.H., Lu Q., Ouyang Y.D., Mao H.L., Zhang P.B., Yao J.L., Xu C.G., Li X.H., Xiao J.H., and Zhang Q.F., 2012, A long noncoding RNA regulates
photoperiod-sensitive male sterility, an essential component of hybrid rice, Proc. Natl. Acad. Sci. USA., 109(7): 2654-2659
PMid:22308482 PMCid:PMC3289353
Gordon D., Huddleston J., Chaisson M.J.P., et al., 2016, Long-read sequence assembly of the gorilla genome, Science, 352(6281): e344
PMid:27034376 PMCid:PMC4920363
Guo C.X., and Liu H., 2014, Structure research and progress of LncRNA, Hebei Yiyao (Hebei Medical Journal), 36(17): 2666-2671
Gupta R.A., Shah N., Wang K.C., et al., 2010, Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis, Nature, 464(7291):
1071-1076
PMid:20393566 PMCid:PMC3049919
Hu G., Gong A., Wang Y., Ma S., Chen X., Chen J., Su C., Shibata A., Strauss-Soukup J., Drescher K., and Chen X., 2016, LincRNA-Cox2 promotes late
inflammatory gene transcription in macrophages through modulating SW I/SNF-Mediated chromatin remodeling, J. Immunol., 196(6): 2799-2808
PMid:26880762 PMCid:PMC4779692
