 
          Computational Molecular Biology 2016, Vol.6, No.4, 1-12
        
        
        
          11
        
        
          Continuing Table 3
        
        
          PFam ID
        
        
          D. discoideum P. infestans T. cruzi
        
        
          PFam
        
        
          Description
        
        
          pfam00069
        
        
          0
        
        
          1
        
        
          15
        
        
          Pkinase
        
        
          Protein kinase domain
        
        
          pfam00085
        
        
          1
        
        
          2
        
        
          14
        
        
          Thioredoxin
        
        
          Thioredoxin
        
        
          pfam00012
        
        
          0
        
        
          1
        
        
          14
        
        
          HSP70
        
        
          Hsp70 protein
        
        
          pfam01764
        
        
          5
        
        
          0
        
        
          14
        
        
          Lipase_3
        
        
          Lipase (class 3)
        
        
          pfam08553
        
        
          0
        
        
          0
        
        
          13
        
        
          VID27
        
        
          VID27 cytoplasmic protein
        
        
          pfam01532
        
        
          2
        
        
          1
        
        
          12
        
        
          Glyco_hydro_47
        
        
          Glycosyl hydrolase family 47
        
        
          pfam03388
        
        
          0
        
        
          0
        
        
          11
        
        
          Lectin_leg-like
        
        
          Legume-like lectin family
        
        
          pfam10479
        
        
          0
        
        
          0
        
        
          11
        
        
          FSA_C
        
        
          Fragile site-associated protein C-terminus
        
        
          pfam00175
        
        
          0
        
        
          0
        
        
          10
        
        
          NAD_binding_1
        
        
          Oxidoreductase NAD-binding domain
        
        
          pfam00106
        
        
          1
        
        
          0
        
        
          9
        
        
          adh_short
        
        
          short chain dehydrogenase
        
        
          pfam13458
        
        
          0
        
        
          0
        
        
          9
        
        
          Peripla_BP_6
        
        
          Periplasmic binding protein
        
        
          pfam00450
        
        
          2
        
        
          2
        
        
          8
        
        
          Peptidase_S10
        
        
          Serine carboxypeptidase
        
        
          pfam10446
        
        
          0
        
        
          1
        
        
          8
        
        
          DUF2457
        
        
          Protein of unknown function (DUF2457)
        
        
          pfam11052
        
        
          0
        
        
          0
        
        
          8
        
        
          Tr-sialidase_C
        
        
          Trans-sialidase of Trypanosoma
        
        
          pfam00226
        
        
          1
        
        
          4
        
        
          7
        
        
          DnaJ
        
        
          DnaJ domain
        
        
          pfam02777
        
        
          0
        
        
          0
        
        
          7
        
        
          Sod_Fe_C
        
        
          Iron/manganese superoxide dismutases
        
        
          pfam00160
        
        
          1
        
        
          1
        
        
          6
        
        
          Pro_isomerase
        
        
          Cyclophilin type peptidyl-prolyl
        
        
          pfam00004
        
        
          0
        
        
          1
        
        
          6
        
        
          AAA
        
        
          ATPase family associated with various cellular
        
        
          pfam03985
        
        
          0
        
        
          0
        
        
          6
        
        
          Paf1
        
        
          Paf1
        
        
          pfam07999
        
        
          0
        
        
          0
        
        
          6
        
        
          RHSP
        
        
          Retrotransposon hot spot protein
        
        
          pfam13868
        
        
          0
        
        
          0
        
        
          6
        
        
          TPH
        
        
          Trichohyalin-plectin-homology domain
        
        
          Note: The table only contains protein families having 6 or more members in a species. A complete list can be found as supplementary
        
        
          Table3
        
        
          References
        
        
          Bakthavatsalam D., and Gomer R.H., 2012, The secreted proteome profile of developing
        
        
          Dictyostelium discoideum
        
        
          cells, Proteomics, 10: 2556-2559
        
        
        
          Bendtsen J.D., Nielsen H., von Heijne G., and Brunak S., 2004, Improved prediction of signal peptides: SignalP 3.0, Journal of Molecular Biology, 340(4):
        
        
          783-795
        
        
        
          Bern C., Kjos S., Yabsley M.J., and Montgomery S.P., 2011, Trypanosoma cruzi and Chagas' disease in the United States, Clinical Microbiology Reviews, 24(4):
        
        
          655-681
        
        
        
          Bhatt T.K., 2012, Malaria Parasite ‘Secretome’: A Potential Drug Target, Research and Reviews: Journal of Computational Biology, 1(2): 1-5
        
        
          Watanabe C.R., Da S.J., and Bahia D., 2016, Interactions between trypanosoma cruzi secreted proteins and host cell signaling pathways, Frontiers in
        
        
          Microbiology, 7(e102)
        
        
        
          D'Acremont V., Lengeler C., and Genton B., 2010, Reduction in the proportion of fevers associated with plasmodium falciparum parasitaemia in Africa: a
        
        
          systematic review, Malaria Journal, 9(1): 1
        
        
        
          Emanuelsson O., Brunak S., von Heijne G., and Nielsen H., 2007, Locating proteins in the cell using TargetP, SignalP and related tools, Nature Protocols, 2(4):
        
        
          953-971
        
        
        
          Foissner W., 1999, Protist diversity: estimates of the near-imponderable, Protist, 150: 363-368
        
        
        
          Foissner W., 2006, Biogeography and dispersal of micro-organisms: a review emphasizing protists, Acta Protozoologica, 45: 111-136
        
        
          Hiller N.L., Bhattacharjee S., van Ooij C., Liolios K., Harrison T., Lopez-Estrano C., and Haldar K., 2004, A host-targeting signal in virulence proteins reveals a
        
        
          secretome in malarial infection, Science, 306(5703): 1934-1937
        
        
        
          Horton P., Park K.J., Obayashi T., Fujita N., Harada H., Adams-Collier C.J., and Nakai K., 2007, WoLF PSORT: protein localization predictor, Nucleic Acids
        
        
          Research, 35(suppl 2): W585-W587
        
        
        
          Käll L., Krogh A., and Sonnhammer E.L., 2007, Advantages of combined transmembrane topology and signal peptide prediction—the Phobius web server,