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Computational Molecular Biology 2015, Vol. 5, No. 1, 1-13
http://cmb.biopublisher.ca
9
von Heijne, 1990). In this study we found most parts
of consensus sequence which were susceptible to
O-glycosylation for instance in HBA potential
O-glycosylated as illustrated in Ser3-Ser4-Thr8 for
domestic camels and Ser4-Thr42 for human (Table 4).
The based on Table 4, alpha hemoglobin is potentially
susceptible to O-glycosylation specially
Camelus
ferus
. As showed O-glycosylation for HBB in Table 3,
Table 4 The predicted N-, O- and C-Glycosylation sites of hemoglobin (Alpha and Beta subunits) in
Camelus
family and human
(
Homo sapiens
). Glycosylation type, position of glycosylation in consensus sequence and prediction of glycosylation are illustrated
following
Protein
Glycosylation Type
Position
Sequence
Prediction
HBA
Camelus bactrianus
and
dromedarius
N- glycosylation
9
N
VK
Non-glycosylated
97
N
FK
Non-glycosylated
131
N
VS
Potential glycosylated
O- glycosylation
3
S
Potential glycosylated
4
S
Potential glycosylated
8
T
Potential glycosylated
12
T
Non-glycosylated
38
T
Non-glycosylated
39
T
Non-glycosylated
41
T
Potential glycosylated
49
S
Non-glycosylated
52
S
Non-glycosylated
HBA
Camelus ferus
N- glycosylation
10
N
VK
Non-glycosylated
98
N
FK
Non-glycosylated
132
N
VS
Potential glycosylated
O- glycosylation
4
S
Potential glycosylated
5
S
Potential glycosylated
9
T
Non-glycosylated
13
T
Non-glycosylated
39
T
Potential glycosylated
40
T
Potential glycosylated
42
T
Potential glycosylated
50
S
Potential glycosylated
53
S
Non-glycosylated
68
T
Non-glycosylated
79
S
Non-glycosylated
82
S
Potential glycosylated
85
S
Potential glycosylated
103
S
Non-glycosylated
109
T
Non-glycosylated
119
T
Potential glycosylated
121
S
Non-glycosylated
125
S
Potential glycosylated
134
S
Non-glycosylated
135
T
Non-glycosylated
138
T
Potential glycosylated
139
S
Potential glycosylated
HBA
Homo sapiens
N- glycosylation
10
N
VK
Non-glycosylated
69
N
AV
Non-glycosylated
79
N
AL
Non-glycosylated
98
N
FK
Non-glycosylated
4
S
Potential glycosylated
9
T
Non-glycosylated
36
S
Non-glycosylated