Cancer Genetics and Epigenetics 2019, Vol.7, No.1, 1-10
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Figure 4 Forest plot
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgPro + ArgArg VS. ProPro
genetic model
Figure 5 Forest plot
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgArg VS. ProPro + ArgPro
genetic model
2 Discussion
The TP53 codon 72 encode Arg and Pro, which are two different functional alleles. And the most informative
polymorphism in the TP53 gene is Pro to Arg, which have been found to be associated with the tumors (Ara et al.,
1990; Hollstein et al., 1991). Some articles showed an increased risk of disease, among the published publications
which explore the relation in the polymorphism and tumors (Xu et al., 2012; Zhou et al., 2012), but some persons
could not to find any relation (Matakidou et al., 2003; Sousa et al., 2007; Zhou et al., 2007). The different
systematic reviews of the same tumor type could get opposite results, and this is an interesting phenomenon,
which is the result from these meta-analyses. Such relation among the people is unclear, although some
conclusions were reached by one meta-analyses which studied the relation of the TP53 codon 72 polymorphism
