Cancer Genetics and Epigenetics 2019, Vol.7, No.1, 1-10
1
Research Article Open Access
Association between the TP53 Codon 72 Polymorphism and Risk of
Nasopharyngeal Carcinoma: AMeta-analysis
Chenggang Mao
1
*
, Xiaochun Zhou
1
*
, Yidao Jiang
1
, Lijia Wan
1
, Zezhang Tao
2
1 Department of Otolaryngology-Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou,
434020, China
2 Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China
*
These authors contributed equally to this work
Corresponding author email
Cancer Genetics and Epigenetics, 2019, Vol.7, No.1 doi
Received: 24 Jan., 2019
Accepted: 13 Feb., 2019
Published: 22 Feb., 2019
Copyright © 2019
Mao et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:
Mao C.G., Zhou X.C., Jiang Y.D., Wan L.J., and Tao Z.Z., 2019, Association between the TP53 codon 72 polymorphism and risk of nasopharyngeal
carcinoma: a meta-analysis, Cancer Genetics and Epigenetics, 7(1): 1-10 (doi
Abstract
The associations of the P53 codon 72 polymorphism and risk of nasopharyngeal carcinoma (NPC) were inconclusive in
several epidemiological studies. In order to get a more consistent result in these two, we conducted these 9 articles of the
meta-analysis and systemic reviews to investigate relationships. An exhaustive search was conducted by us in PubMed and Embase
databases up to March 2015. Only the studies consisting of NPC patients who were diagnosed by pathological methods were
considered. The 95% confidence intervals (CIs) of odds ratios (ORs) were used to assess the association and Review Manager
(RevMan) 5.2 software were used to perform statistical analyses. Consequently, there were nine studies were selected, which include
1,588 cases and 1,925 controls met the included criteria. Ultimately, systematic meta-analyses were used to extract relevant data and
further analyze. The conclusions indicated that the persons who carried Pro/Pro genotype have an increased susceptibility of NPC
compared with the persons who carried homozygote Arg/Arg genotype and heterozygote Arg/Pro [OR 0.59, 95% CI 0.48-0.72; OR
0.66, 95% CI 0.46-0.93]. For Arg allele, the persons with homozygote Pro/Pro genotype have an obviously increased susceptibility to
NPC to the persons with an integrated Arg genotype (Arg/Pro + Arg/Arg) [OR 0.62, 95% CI 0.45-0.68]. For Pro allele, the
conclusions showed the persons with Arg/Arg genotype have an obviously increased risk of NPC compared with the persons with an
integrated Pro genotype (Arg/Pro + Pro/Pro) [OR 0.75, 95% CI 0.64-0.87]. To sum up, the conclusions of the meta-analysis indicate
that Homozygote Pro/Pro genotype obviously increased NPC risk in the P53 codon 72; and Arg allele significantly decreased the
susceptibility to NPC.
Keywords
TP53 codon 72; Nasopharyngeal carcinoma; Meta-analysis; Polymorphism
Background
Nasopharyngeal carcinoma (NPC) is an illness which related with geographic distribution and distinct ethnic.
NPC has an obvious disease burden in Southern China and Southeast Asia, which has an annual about 20 per
100,000 people incidence rate in endemic areas, but is relatively seldom in the Western world (Jeannel and
Bouvier, 1999; Parkin et al., 2002). This tumor has been suggested to result from complex interactions of a variety
of epidemiological factors. There was evidence which shows that tobacco smoking, alcohol consumption,
infection of Epstein-Barr virus (EBV), more exposure of wood dust and a high-salt diet consumption may be risk
factors for NPC (Zheng et al., 1994; Cheng et al., 1999; Key et al., 2004; Gullo et al., 2008; Jayaprakash et al.,
2008). Only a few exposed persons of exposed people were developed to NPC, which imply that many
interactions in some environmental and genetic factors may be the main reason of NPC, and the carcinogenic
mechanisms may be contributed by genetic factors, although the risk factors exposed to many persons.
The tumor protein p53 gene, which located on chromosome 17p13, we called TP53, is one of the most likely
mutated genes in human tumors and it is probably to be an obviously decisive factor in form of tumor (Tsui et al.,
2009). The codon 72 polymorphism, located in exon 4 of TP53 gene, which called rs1042522 involves a leading
to a proline (Pro)→arginine (Arg) amino acid substitution CCC→CGC transition at position 72 (Pro72Arg) (Ara
et al., 1990). Many publications have showed that the TP53 codon 72 polymorphism could be connected with
increased risk to bladder tumor (Zhou et al., 2012), cervical cancer (Xu et al., 2012). Although in some NPC cases
