Cancer Genetics and Epigenetics 2019, Vol.7, No.1, 1-10
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Figure 2 Forest plot
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgArg VS. ProPro genetic
model
Figure 3 Forest plot
Note: This represents the NPC risk associated with the TP53 codon 72 polymorphism in Asians for the ArgPro VS. ProPro genetic
model
The meta-analysis indicated the persons who carry homozygote Arg/Arg genotype and heterozygote Arg/Pro have
a decreased susceptibility of NPC compared with those who carry Pro/Pro genotype [OR 0.59, 95% CI 0.48-0.72;
OR 0.66, 95% CI 0.46-0.93]. For Arg allele, the persons who carry an integrated Arg genotype (Arg/Pro +
Arg/Arg) have an obviously decreased risk to NPC relative to the ones who with homozygote Pro/Pro genotype
[OR 0.62, 95% CI 0.45-0.68]. For Pro allele, the meta-analysis showed that the persons who with an integrated
Pro genotype (Arg/Pro + Pro/Pro) have a marked decreased susceptibility of NPC compared with the ones who
with Arg/Arg genotype [OR 0.75, 95% CI 0.64-0.87].
1.3 Publication bias
A relatively symmetrical distribution was showed by a based on the four genetic model funnel plot, which enable
us to deduce that there was no publication bias.
