International Journal of Molecular Medical Science, 2025, Vol.15, No.5, 214-223 http://medscipublisher.com/index.php/ijmms 221 7 Future Outlook and Conclusions The field of regenerated dressings is developing rapidly. The relevant research mainly focuses on multifunctional, intelligent and bionic materials, which can actively participate in the healing process. The combination of nanotechnology, stem cell dressings, 3D biopharmaceuticals and bioactive molecules is transforming traditional wound care methods by enhancing compatibility, accelerating regeneration and releasing drugs as needed. The new generation of dressings strives to imitate the scar-free regeneration mechanism of the fetal period, reduce scar formation, restore the complete structure and function of the skin, and even repair hair follicles and glands. Interdisciplinary collaboration among materials science, bioengineering and clinical medicine has laid a solid foundation for the development of more efficient and targeted personalized treatment methods. Recent in-depth research on the molecular mechanisms of wound healing has driven the design of dressings targeting specific signaling pathways, which can regulate inflammation, promote angiogenesis and accelerate tissue remodeling. New technologies such as gene therapy, exosome delivery and biomolecular carrier scaffolds are moving from experiments to clinical practice, bringing new ideas for solving the complex problems of chronic wounds. However, these schemes still face obstacles in terms of safety, stability and large-scale application, and further research is needed to narrow the gap between experiments and clinical practice. The development of precision medicine and multidisciplinary collaboration has pushed wound regeneration to a new stage. New diagnostic techniques, such as biomarker detection and image analysis, can formulate personalized treatment plans based on molecular signals and cellular characteristics. Doctors, materials experts, engineers and data scientists work closely together to drive innovations in smart dressings, wearable sensors and telemedicine systems, enabling real-time wound monitoring and flexible management. Interdisciplinary collaboration holds promise for providing more efficient, sustainable and patient-centered solutions for chronic wounds, and can also continuously optimize and improve treatment methods. Acknowledgments I extend my sincere thanks to Mrs Su for her feedback on the manuscript. Conflict of Interest Disclosure The author affirms that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Allen J., 2022, IL-4 and IL-13: regulators and effectors of wound repair, Annual Review of Immunology, 41: 229-254. https://doi.org/10.1146/annurev-immunol-101921-041206 Anand K., Sharma R., and Sharma N., 2024, Recent advancements in natural polymers-based self-healing nano-materials for wound dressing, Journal of biomedical materials research, Part B Applied biomaterials, 112(6): e35435. https://doi.org/10.1002/jbm.b.35435 Atepileva A., Ogay V., Kudaibergen G., Kaukabaeva G., Nurkina A., Mukhambetova A., Balgazarov S., Batpen A., Saginova D., Ramazanov Z., Balgazarov A., and Akhmetkarimova Z., 2024, Exploring the antibacterial and regenerative properties of a two-stage alginate wound dressing in a rat model of purulent wounds, Biomedicines, 12(9): 2122. https://doi.org/10.3390/biomedicines12092122 Bakshi S., Sahoo P., Li K., Johnson S., Raxworthy M., and Krauss T., 2023, Nanophotonic and hydrogel-based diagnostic system for the monitoring of chronic wounds, Biosensors and Bioelectronics, 242: 115743. https://doi.org/10.1016/j.bios.2023.115743 Cavallo I., Sivori F., Mastrofrancesco A., Abril E., Pontone M., Di Domenico E., and Pimpinelli F., 2024, Bacterial biofilm in chronic wounds and possible therapeutic approaches, Biology, 13(2): 109. https://doi.org/10.3390/biology13020109 Chen Y., Wang X., Tao S., Wang Q., Ma P., Li Z., Wu Y., and Li D., 2023, Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties, Military Medical Research, 10(1): 37. https://doi.org/10.1186/s40779-023-00473-9 Chou K., Chen C., Cherng J., Li M., Wen C., Hu S., and Wang Y., 2021, Cutaneous regeneration mechanism of β-sheet silk fibroin in a rat burn wound healing model, Polymers, 13(20): 3537. https://doi.org/10.3390/polym13203537
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