International Journal of Clinical Case Reports 2015, Vol.5, No. 45, 1-6
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Patients underwent a clinical analysis of anthropometric
parameters (height and weight) to diagnosis, early and
during puberty and late growth.
A monitoring puberty also was performed in all patients;
it was reported the age at puberty, their progression
and age of menarche in girls.
A Careful analysis of the importance of height and
weight deficit was performed for each patient by
comparing the weight and height to the referential
values for the age on the Sempéand Pedron curves
(expressed in standard deviation (SD) according to the
reference tables expressed in standard deviations score
(SDS) (Perelman and Perelman, 1994; Sempe, 1979)
and in relation to parental target height calculated using
the formula) (Perelman and Perelman, 1994) and in
relation to parental target height (TC): TC = father
height (cm) + mother height (cm)
13 depending to the
sex 2NB: + 13 in boys and - 13 in girls.
Secondary sexual characteristics and course of puberty
were evaluated from the classification of Tanner and
Marshall (1976).
The results were analyzed with computer software Epi
Info Version 6.4 after recording data on individual entry
form. The methods used were: -The calculation of
arithmetic averages (X ±SD). The comparison between
two averages is based on student test and the reduced
difference.
-Arithmetic percentages calculation (p%). The
comparison between two percentages is based on the
chi 2 test and the reduced difference. The significance
rate was p <0.05.
Results:
The growth retardation is severe in GH patients whether
expressed in DS or SDS with no significant difference
between the sexes (DNS).
The calculation of the average growth rate of patients
during the year prior to treatment initiation by GHr
shows that the growth rate is significantly reduced
compared with the theoretical growth rate: 2.6±0.4
cm/year vs. 5 cm / year (P <10-6).71.7% of patients
had a spontaneous pubertal development. The average
age at onset of puberty in girls is 13.9 years
2.8
years (11.5 to 18).
The average age at the end of puberty in girls is 17.4
2.8 years (15-23). The age at the end of puberty in
girls is more delayed than that given by Marshall (p
<0.005).
The age of menarche in girls was 15.5
2 years
(14-20).This average age is significantly delayed
compared with the theoretical age given by Marshall p
<005.
The average course of puberty in girls was 3.1
1,1
years (2.2 to 5). This is comparable to the theoretical
average course of puberty.
The age of menarche in those girls was 15.5
2 years
(14-20).This average age is significantly delayed
compared with the theoretical age given by Marshall p
<005.
The average course of puberty in girls was 3.1
1,1
years (2.2 to 5). is comparable to the theoretical
average course of puberty.
In boys: the average age of onset of puberty is 16.4
2.4 years (12.4 to 19). This age is delayed compared
with that given by Marshall (p <0.001).
The average age at the end of puberty is 19.8
2.2
years (16-23). This average age is later than that
given by Marshall (p<0.000 5).
The average duration of the course of puberty is
normal of 3.7
0.7 years (3 -6).
Delayed puberty is higher in boys than in girls (p
<0.04).
The final height of GH patients who completed their
puberty is very low among both boys and girls with no
significant difference between them.
Discussion
The causes of short height are numerous and their
respective frequency differs slightly depending on
whether it relates to paediatrics or endocrinology
(Vimpani et al., 1977; Job and Pierson, 1981; Bao et al.,
1992; Bessona et al., 2003)
Although the growth hormone deficiency is not
involved in a little less than 10% of growth delays, its
recognition is important because it leads to a specific
treatment that improves stature prognosis (Job and
Pierson, 1981).
