International Journal of Clinical Case Reports 2015, Vol.5, No. 45, 1-6
1
Research Report Open Access
Final Height and Pubertal Development in 150 Children with Growth Hormone
Deficiency in Algeria
Fedala S.N.
1
, Chentli F.
2
, Meskine D.
2
, HaddamA.E.M
2
1. Department of endocrinology bab el oued hospital, Algeria
2. Department of endocrinology bologhine hospital, Algeria
Corresponding author email: Menelik.
International Journal of Clinical Case Reports, 2015, Vol.5, No.45 doi: 10.5376/ijccr.2015.05.0045
Received: 16 Jun., 2015
Accepted: 25 Aug., 2015
Published: 12 Oct., 2015
Copyright
©
2015 Fedala et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:
Fedala S.N., Chentli F., Meskine D.,and Haddam A.E.M., 2015, Final Height and Pubertal Development in 150 Children with Growth Hormone Deficiency in
Algeria, International Journal of Clinical Case Reports, 5(45) 1
-
6
Summary
Growth Hormone Deficiency (GHD) may happen when the body is unable to produce enough growth hormone (GH) or
use it effectively. GH plays a fundamental role in helping young bodies grow and develop puberty. When levels of GH are too low,
there may be an impact on growth and many functions of the body.We report in this study, the results on the final height and pubertal
development of 150 Algerian patients followed in our department of endocrinology.
The average age at diagnosis was 8 ±2.4 in girls and 9 ±1.2 in boys. The GH deficiency was isolated in half of the cases, associated
with other hypophyseal deficits in the other half; hormonal deficiencies were all substituted. Patients received irregular treatment
with GHr the average height of patients GHD at diagnosis in boys: -4,7DS ±1,8) /(Sempé) and -4,1DS 0,8/ TC; In girls -4,9DS ±
2,3(- 11,8, - 2,8)/(Sempé) and -5, 2 1,2/TC.
Average final height: -3,4 1,02/ Sempé; - 2,1 1,1/TC in boys and - 3,8 1,06/ Sempéand - 3,8 1,03/TC in girls. The average age at
onset of puberty in girls: 13.9 2.8 years. At the end of puberty: 17.4 2.8 years. The age of menarche: 15.52 years. In boys, the average
At the end of puberty: 19.8 2.2 years. The average duration of the course of puberty is 3.7 0.7 years in boys, 3.1 1,1 years in girls.
Delayed puberty is higher in boys than in girls (p <0.04).
Keywords
GH deficiency; GHr; Final height; Puberty
Introduction
Growth Hormone Deficiency may happen when the
body is unable to produce enough growth hormone (GH)
or use it effectively. GH plays a fundamental role in
helping young bodies grow and develop, including
improving muscle metabolism, growing bones, and
breaking down fats.When levels of GH are too low,
there may be an impact on growth and many functions
of the body (Job, 1983) (Carroll and Christ) (Barat,
1999) (G.H. Research society, 2000).
Objective: To determine final height and puberty in
children with GH deficiency (GHD) who have completed
puberty.
Population, Methodology
This is about a prospective, longitudinal analytical
study of 150 GHD patients whose diagnosis was based
on a set of clinical and para-clinical arguments (G.H
research society, 2000): Anamnestic and clinical
characteristics GH deficiency, Radiological assessments
(AO), Non-hormonal biological assessments of orientation,
the low rate of IGF1 and the negative answer to both
pharmacological tests of GH stimulation. The average
age at diagnosis was 8 ±2.4 (7-19) in girls and 9 ±1.2
(8-18) in boys. The GH deficiency was isolated in half
of the cases (51%), associated with other hypophyseal
deficits in the other half (49%): gonadotropic 28%,
TSH + ACTH: 18.63% - ACTH1: 4.01% - TSHus:
13.08% - diabetes insipidus: 3.73%. Hormonal
deficiencies were substituted. Patients received irregular
treatment with recombinant growth hormone (GHr)
due to frequent breakdown of the product during the
follow-up period or lack of resources because the
treatment was not paid in any case.
The treatment was stopped when the growth rate was
residual (less than 2 cm/year) with an age greater than
15 years.
