Cancer Genetics and Epigenetics 2015, Vol.3, No.12, 1-7
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Table 1 The KEGG pathway of significantly DEGs
Term
Count
FDR
hsa04080:Neuroactive ligand-receptor interaction
7
0.008359
hsa05130:Pathogenic Escherichia coli infection
4
0.007338
Figure 2 The gene ontology of significantly DEGs.
plays an important role in development of sex.
DEGs are also enriched in Neuroactive ligand-
receptor interaction, which are mainly involved in
osteoporosis, sexual precocity and ovarian hy
-perstimulation syndrome. It means that this kegg
pathway has strong correlation with prolactinoma
(Decker et al., 2008; Frimberger and Gearhart, 2005;
Bertelloni and Mul, 2008; Kasum, 2010).
In PPI network, MDM2, LYN, CDH1, GH1, ACTG1
and FUS have high degrees and are regarded as hub
genes. It demonstrates that these genes are important
in interaction and biological process. MDM2 can
encode an ubiquitinligating enzyme which can
regulate tumor suppressor gene and promote the
progress of tumors(Huang et al., 2014). Besides, GH1
is a member of prolactin family, and the abnormity of
this gene can influence the secretion of prolactin,
which can inhibit the growth and development of
sex(Vakili et al., 2014). In conclusion, these genes
play important roles in prolactinoma.
We recognize many motifs and choose a most
significant motif for the analysis. This motif includes
GAL, GALR1, GALR2, GALR3 and GPR151.
GALR1 and GALR2 are the members of galanin
family. Galanin can influence nervous system
and endocrine system and the abnormity of these
genes can destroy the growth and development of
mammals(Wynick et al., 1998). Besides they can also
effect the secretion of prolactinoma. Therefore galanin
can be regarded as the biomarker of cu ring
prolactinoma. We also identify mir124 and mir21
which have strong correlation with nervous system.
The differential expression of these miRNAs can
regulate many nervous system diseases and prolactinoma
is one of nervous system disease (Guo et al., 2009;
Chen et al., 2004). Furthermore they are also
