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Identification of the
Bona fide
Differentially Methylated Gene Markers among Cancers
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Figure 2 Methylation patterns of C-DMSs, T-DMSs, Cs-UMSs and T-UMSs
Note: (A) Methylation heat map across six cancers of CpGs ranked by entropy derived from QDMR. (B) Methylation heat map
across five tissues of CpGs ranked by entropy derived from QDMR. (C-F) Methylation levels of C-DMSs, T-DMSs, Cs-UMSs and
T-UMSs, respectively
Figure 3 Overlap of T-DMRs and Cs-DMRs
1.6 Identificaiton of potential cancer-related genes
by protein interaction sub-network
Furthermore, we obtained a sub network from the
protein interaction network by selecting the proteins
coded by the genes with
bona fide
C-DMSs and their
nearest neighbor proteins (Figure 4A). It is shown that
the proteins coded by the genes with
bona fide
C-DMSs are prone to interact with other proteins. In
this network, ACSM3 are interacted with most proteins,
and this gene has been reported to be associated with
liver, colon and breast cancer (Chen et al., 2002). In
Computational
Molecular Biology