International Journal of Marine Science, 2016, Vol.6, No.20, 1-6
1
Research Report Open Access
Identification of Novel Metabolites along with the Assessment of Metal Toxicity
and Its Implication in Marine Red alga
Hypnea musciformis
D. Isaac Dhinakaran , P. Karthick raja, K. Krishna kumar, G. Vigneshwaran, T. Marimuthu
Department of Biotechnology, Ayyya Nadar Janaki Ammal College, Sivakasi-626124, Tamilnadu, India
Corresponding email
International Journal of Marine Science 2016, Vol.6, No.20 doi
Received: 24 Mar., 2016
Accepted: 12 May, 2016
Published: 12 May, 2016
Copyright
© 2016 This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article
:
Dhinakaran D.I., Karthickraja P., Kumar K.K., Vigneshwaran G., and Marimuthu T., 2016, Identification of Novel metabolites along with the Assessment of
Metal Toxicity and Its Implication in Marine Red alga
Hypnea musciformis
), International Journal of Marine Science, 6(20): 1-6 (do
Abstract
Marine algae are known to contain a wide variety of bioactive compounds, biomaterials derived from marine algae have
commercial applications in pharmaceutical, medical, cosmetic, nutraceutical, food and agricultural industries. Marine algae are found
to contain high amount of nutrients, vitamins (A, B, C, D & E), minerals (Ca, P, Na & K), antioxidants and dietary fibers, that’s why
they are used as food, fodder and other commercial purposes throughout the world. Seaweeds have been used as an important source
of food because of their biochemical composition. They are also very rich in novel compounds and can be explored for the
development of drugs to combat deadly diseases like cancer, diabetes etc. The present study indicates the presence of bioactive
compounds by using HPLC and FTIR in marine algae
Hypnea musciformis
. It includes polysaccharides, terpenes, alkenes, sterols etc.
These results indicated that seaweeds
H. musciformis
could be potential sources of development novel bioactive compounds.
Similarly the heavy metals analyzed were found in less concentration and does not have any effects. It was (Cd, Fe, Cu, Ca, Cr, Pb,
Ni, Co, Mn, Zn) metals were estimated using atomic absorption spectroscopy. Seaweeds can provide a dietary alternative due to its
nutritional value and its commercial value can be enhanced by improving the quality and expanding the range of seaweed-based
products. In the future, these marine algae-derived materials/compounds will be used more often in pre-clinical studies for drug
discovery.
Keywords
H. musciformis
; Heavy metals; Bioactive compounds; HPLC; FTIR
Introduction
The world’s oceans, covering more than 70% of the earth s surface, represent an enormous resource for the
discovery of potential therapeutic agents. During the last decades, numerous novel compounds have been found
from marine organisms with interesting pharmaceutical activities. Therefore, marine organisms are believed to be
a potential source to provide not only novel biologically active substances for the development of pharmaceuticals
(Burja et al., 2001). Seaweeds are classified as Green algae (Chlorophyta), Brown algae (Phaeophyta), Red algae
(Rhodophyta) and some filamentous Blue-green algae (Cyanobacteria). Most of the seaweeds are red
(6000species) and the rest known are brown (2000 species) or green (1200 species) (Kohen and Nyska, 2002).
Marine algae are rich in dietary fiber, minerals lipids, proteins, omega-3 fatty acids, essential amino acids,
polysaccharides, and vitamins A, B, C, and E. Studies on the bioactivities of marine algae have revealed numerous
health-promoting effects, including anti-oxidative, anti-inflammatory, antimicrobial, and anti-cancer effects
(Tabarsa et al., 2012). The use of marine natural products able to inhibit bacteria development offers a rich
pharmacological potential. Numerous reports show that macroalgae present a broad range of biological activities
such as antibacterial antifungal antiviral and anti-inflammatory (Etahiri et al., 2003) In contrast to the brown and
green algae, the red algae are more known to produce halogenated metabolites, particularly bromine and iodine.
To date, many chemically unique compounds of marine origin with various biological activities have been isolated
and some of them are under investigation and are being used to develop new pharmaceuticals compounds (Lima
Filho et al., 2002).
Distinctive structure of viruses and their complicated lifecycle have made the discovery of definite treatments
against antiviral infections extremely demanding. Despite comprehensive Studies for suitable vaccines and
