| Research Article | 4 |
| Abstract | 4 |
| Keywords | 4 |
| Background | 4 |
| 1 Results | 5 |
| 2 Discussion | 9 |
| 3 Materials and methods | 11 |
| Author’s contributions | 12 |
| Acknowledgments | 12 |
| References | 12 |
| Table 1 | 5 |
| Figure 1 | 6 |
| Figure 2 | 6 |
| Figure 3 | 6 |
| Figure 4 | 6 |
| Table 2 | 7 |
| Table 3 | 7 |
| Table 4 | 7 |
| Table 5 | 7 |
| Table 6 | 8 |
| Table 7 | 8 |
| Table 8 | 8 |
| Table 9 | 9 |
| Figure A | 14 |
| Figure B | 14 |
| Figure C | 14 |