International Journal of Clinical Case Reports 2017, Vol.7, No.12, 49-52
49
Research Report Open Access
Collodion Baby: Case Report
Ragmoun H.
1
, Daadoucha A.
2
, Benhlima N.
3
, Ajili A.
1
1 Department of Obstetric Gynecology Ibn El Jazzar Hospital Kairouan, University hospital assistant in gynecology obstetrics, Ibn El Jazzar street, Kairouan
3100, Tunisia
2 Department of Radiology Ibn El Jazzar Hospital Kairouan, University hospital assistant in radiology, Ibn El Jazzar street, Kairouan 3100, Tunisia
3 Department of Cardiology Ibn El Jazzar Hospital Kairou, University hospital assistant in cardiology, Ibn El Jazzar street, Kairouan 3100, Tunisia
Corresponding author email
International Journal of Clinical Case Reports 2017, Vol.7, No.12 doi
Received: 16 Aug., 2017
Accepted: 09 Oct., 2017
Published: 20 Oct., 2017
Copyright © 2017
Ragmoun et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:
Ragmoun H., Daadoucha A., Benhlima N., and Ajili A., 2017, Collodion baby: case report, International Journal of Clinical Case Reports, 7(12): 49-52
(doi
Abstract
The purpose of this work is to analyse the present data concerning epidemiological aspects, therapeutic possibilities as
well as prenatal diagnosis of collodion baby. We report the case a woman, having a case index in the family and that consulted for a
threat of premature childbirth to 29 weeks of amenorrhoea. Following have been marked by a premature childbirth of masculine sex
newborn, presenting dermatological lesions typical of collodion baby, whose evolution was quickly fatal since first hours of life.
Collodion baby is a severe form of congenital ichthyosis presents at birth. The clinical table is often characteristic. The prognosis
depends on the management in the early neonatal period.
This disorder usually evolves into a nonbullous congenital ichthyosiform
erythroderma.
Thanks to techniques of molecular biology, the prenatal diagnosis is given back possible since the 10-12 weeks of
amenorrhoea, permitting a genetic counseling.
Keywords
Congenital ichthyosis; Collodion baby; Genetic diagnosis
Background
Congenital ichtyosis type baby collodion is a rare genetic cutaneous disease (Hohl, 2004). Its name comes from the
Greek "ichthys" meaning "fish" and referring to the clinical appearance of a scaly skin (
Alam, 2004
). It causes
hyperkeratinization of the epidermis. The skin then becomes thick and tough, with deep cracks on its surface
(Larrégue et al., 2008).
This initial expression is common to the various disorders of epidermal differentiation and can be observed in
different types of ichthyoses. This is the preferential starting mode of the large recessively transmitted ichthyoses
(Saurat, 2004).
The condition is due to the retention of an abnormal corneal layer in utero (Mallory, 2007). Indeed, the
pathological process affects the formation, maintenance and function of the stratum corneum (Williams and Elias,
2000).
The prognosis of the disease depends on several parameter: the degree of initial attack, duration of desquamation,
and the underlying ichthyosis.
1 Observation
F.A, 34 years old, with no significant pathological history, having as gyneco-obstetric history a late abortion in the
fourth month and a preterm birth at 28 SA of a baby weighing 800 g and presenting generalized dermatological
lesions recalling the collodion baby. She consulted us for pelvic pain type of uterine contractions on a 33
amenorrhea week’s pregnancy.
On clinical examination, uterine contractions were regular and painful, uterine height at 27 cm and vaginal touch a
shortened cervix, open to a finger with bulging Water pouch.
