International Journal of Aquaculture, 2017, Vol.7, No.5, 31
-
41
39
due to hypoxia, limiting temperature or the activity of dietary or environmental toxins (Tang and Chen, 2003).
Also, in this study, dietary FB1 caused significant increases in the serum concentration of ALP and LDH in fish
fed diets amended with fumonisin B1 signifying injuries to the hepatobiliary tracts (Pepeljnjak et al., 2002; Tuan
et al., 2003).
According to McCue (2010), serum lipids particularly serum total cholesterol and serum triglycerides
concentrations are dependent on the nutritional and or physiological statuses of the fish. Malnutrition and or
starvation cause a decrease in the serum concentration of total cholesterol and an increase in the serum triglyceride
concentration (Perez-Jimerez et al., 2012). The serum lipids (cholesterols, high density lipids, very low density
lipids, low density lipids and triglycerides) were significantly elevated in
H. longifilis
catfish juveniles fed the
diets amended with FB
1
compared to fishes fed the control diets. These increases were dependent on the
concentration of the FB
1
contents in the diets and also on the duration of the feeding exposure. Increased serum
lipids concentration may be due to hepatocellular degeneration and dysfunction which ultimately impact on the
activity of cytochrome P450 enzymes (Williams and Latropoulos, 2002). Further, the dietary FB
1
may also have
caused a depression of the hepatic activity of lipogenic and cholesterolegenic enzymes (Soriano et al., 2005), a
step precedent upon the development of toxicities reported in chronic FB
1
toxicity studies (Zhang and Du, 2012).
In conclusion, dietary fumonisin B1 initiated significant physio-pathological changes in
Heterobranchus longifilis
catfish juveniles. These changes marked by increased serum activities of liver and kidney marker enzymes, were
also accompanied by significant increases in serum concentrations of total cholesterol, low density cholesterol and
serum triglycerides. Further, dietary inclusions of fumonisin B1 ≤ 24.74 mg. kg
-1
appears to be the safe and
acceptable tolerance levels in juvenile
H. longifilis
catfishes.
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