Computational Molecular Biology 2014, Vol. 4, No. 10, 1-17
            
            
              http://cmb.biopublisher.ca
            
            
              15
            
            
              Supplementary Table 1 Percentage and peak number for all localization type in TSS-proximal regions, non-TSS-proximal regions
            
            
              and all peaks
            
            
              Gene-related peaks
            
            
              me1
            
            
              me1me2 me1me2me3 me1me3 me2
            
            
              me2me3 me3
            
            
              Distribution of TPRs Number
            
            
              5,948
            
            
              1,278
            
            
              536
            
            
              726
            
            
              3,899 1,860
            
            
              13,212
            
            
              Percentage(Number/27459) 0.22
            
            
              0.05
            
            
              0.02
            
            
              0.03
            
            
              0.14
            
            
              0.07
            
            
              0.48
            
            
              Distribution of  non-
            
            
              TPRs
            
            
              Number
            
            
              33,086 1,494
            
            
              991
            
            
              1,907
            
            
              3,124 2,960
            
            
              11,262
            
            
              Percentage(Number/54824) 0.60
            
            
              0.03
            
            
              0.02
            
            
              0.03
            
            
              0.06
            
            
              0.05
            
            
              0.21
            
            
              Distribution of all
            
            
              peaks
            
            
              Number
            
            
              39,034 2,772
            
            
              1,527
            
            
              2,633
            
            
              7,023 4,820
            
            
              24,474
            
            
              Percentage(Number/82283) 0.47
            
            
              0.03
            
            
              0.02
            
            
              0.03
            
            
              0.09
            
            
              0.06
            
            
              0.30
            
            
              Supplementary Table 2 Percentage of conservation for all localization types based on all TPRs
            
            
              OR = 0.1
            
            
              pC cutoff
            
            
              me1me2
            
            
              me1me2me3
            
            
              me1me3
            
            
              me2me3
            
            
              Average
            
            
              Single
            
            
              0.2
            
            
              0.3
            
            
              0.49
            
            
              0.49
            
            
              0.45
            
            
              0.4325
            
            
              0.44
            
            
              0.4
            
            
              0.26
            
            
              0.43
            
            
              0.45
            
            
              0.4
            
            
              0.385
            
            
              0.39
            
            
              0.6
            
            
              0.24
            
            
              0.41
            
            
              0.42
            
            
              0.37
            
            
              0.36
            
            
              0.37
            
            
              0.8
            
            
              0.21
            
            
              0.39
            
            
              0.4
            
            
              0.35
            
            
              0.3375
            
            
              0.34
            
            
              1.0
            
            
              0.17
            
            
              0.33
            
            
              0.34
            
            
              0.28
            
            
              0.28
            
            
              0.29
            
            
              OR = 0.3
            
            
              pC cutoff
            
            
              me1me2
            
            
              me1me2me3
            
            
              me1me3
            
            
              me2me3
            
            
              Average
            
            
              Single
            
            
              0.2
            
            
              0.3
            
            
              0.48
            
            
              0.49
            
            
              0.45
            
            
              0.43
            
            
              0.44
            
            
              0.4
            
            
              0.26
            
            
              0.42
            
            
              0.45
            
            
              0.4
            
            
              0.3825
            
            
              0.39
            
            
              0.6
            
            
              0.24
            
            
              0.4
            
            
              0.42
            
            
              0.37
            
            
              0.3575
            
            
              0.37
            
            
              0.8
            
            
              0.21
            
            
              0.38
            
            
              0.39
            
            
              0.35
            
            
              0.3325
            
            
              0.34
            
            
              1.0
            
            
              0.17
            
            
              0.33
            
            
              0.34
            
            
              0.28
            
            
              0.28
            
            
              0.29
            
            
              OR = 0.5
            
            
              pC cutoff
            
            
              me1me2
            
            
              me1me2me3
            
            
              me1me3
            
            
              me2me3
            
            
              Average
            
            
              Single
            
            
              0.2
            
            
              0.3
            
            
              0.48
            
            
              0.48
            
            
              0.45
            
            
              0.4275
            
            
              0.44
            
            
              0.4
            
            
              0.26
            
            
              0.43
            
            
              0.44
            
            
              0.4
            
            
              0.3825
            
            
              0.39
            
            
              0.6
            
            
              0.24
            
            
              0.4
            
            
              0.41
            
            
              0.37
            
            
              0.355
            
            
              0.37
            
            
              0.8
            
            
              0.22
            
            
              0.38
            
            
              0.39
            
            
              0.35
            
            
              0.335
            
            
              0.34
            
            
              1.0
            
            
              0.17
            
            
              0.33
            
            
              0.33
            
            
              0.28
            
            
              0.2775
            
            
              0.29
            
            
              OR = 0.7
            
            
              pC cutoff
            
            
              me1me2
            
            
              me1me2me3
            
            
              me1me3
            
            
              me2me3
            
            
              Average
            
            
              Single
            
            
              0.2
            
            
              0.3
            
            
              0.48
            
            
              0.47
            
            
              0.46
            
            
              0.4275
            
            
              0.44
            
            
              0.4
            
            
              0.26
            
            
              0.42
            
            
              0.43
            
            
              0.41
            
            
              0.38
            
            
              0.39
            
            
              0.6
            
            
              0.24
            
            
              0.4
            
            
              0.41
            
            
              0.38
            
            
              0.3575
            
            
              0.37
            
            
              0.8
            
            
              0.21
            
            
              0.38
            
            
              0.39
            
            
              0.35
            
            
              0.3325
            
            
              0.34
            
            
              1.0
            
            
              0.17
            
            
              0.32
            
            
              0.33
            
            
              0.29
            
            
              0.2775
            
            
              0.29
            
            
              OR = 1.0
            
            
              pC cutoff
            
            
              me1me2
            
            
              me1me2me3
            
            
              me1me3
            
            
              me2me3
            
            
              Average
            
            
              Single
            
            
              0.2
            
            
              0.32
            
            
              0.57
            
            
              0.45
            
            
              0.48
            
            
              0.455
            
            
              0.44
            
            
              0.4
            
            
              0.27
            
            
              0.51
            
            
              0.42
            
            
              0.44
            
            
              0.41
            
            
              0.39
            
            
              0.6
            
            
              0.25
            
            
              0.49
            
            
              0.4
            
            
              0.41
            
            
              0.3875
            
            
              0.36
            
            
              0.8
            
            
              0.23
            
            
              0.46
            
            
              0.38
            
            
              0.38
            
            
              0.3625
            
            
              0.33
            
            
              1.0
            
            
              0.18
            
            
              0.41
            
            
              0.32
            
            
              0.32
            
            
              0.3075
            
            
              0.28