基本HTML版本
Computational Molecular Biology 2014, Vol. 4, No. 5
http://cmb.biopublisher.ca
6
Table 2 Continue
BACE1-AS
Antisense
to
BACE1
modulates
BACE1
gene
expression;
BACE1-AS
levels are increased in
tissues
from
AD
patients
Alzheimer's disease (AD) (Faghihi et al.,
2008)
BC200
Chromosome 11,
p11.2, an ~600,000
bp region
Increased levels of
BC200
were found in
brain
that
are
preferentially affected
in AD
Alzheimer's disease (AD) (Mus et al., 2007)
ATXN8OS
Antisense
to
ATXN8
implicated
in
the
molecular
pathophysiology
of
SCA8
spinocerebellar
ataxia
type 8 (SCA8)
(Daughters et al.,
2009; Koob et al.,
1999; Moseley et
al., 2006)
An
unnamed
lncRNA
associated with the
cyclin D1 gene
promoter
Recruit FUS/TLS to
repress cyclin D1
amyotrophic
lateral sclerosis (ALS)
(Wang et al.,
2008)
An
unnamed
lncRNA
lncRNA transcripts
derived from the
mouse T early α
(TEA) promoter
Responsible in part for
MS
Multiple sclerosis (MS)
(Huseby et al.,
2012; Friese and
Fugger, 2009)
M21981
nested within
individual introns
of the
IL2RA
gene
is upregulated with
T-cell activation and is
identified by genome-
wide association studies
(GWAS)
to
be
susceptible to MS
Multiple sclerosis (MS)
(International
Multiple Sclerosis
Genetics et al.,
2007)
Tmevpg1
is transcribed from a
cluster of cytokine
genes, neighboring
Ifng
Is associated with a MS
mouse model
Multiple sclerosis (MS)
(Vigneau et al.,
2003)
H19
With
IGF2
in the
same cluster
Deregulated
H19
is
associated with various
diseases
medulloblastomas,
meningiomas and gliomas
(Albrecht et al.,
1996; Yoon et al.,
2002; Muller et
al., 2000; Berteaux
et al., 2005)
anti-NOS2A
Antisense
to
NOS2A
is evolved by duplication
of the
NOS2A
gene
followed by internal
DNA inversion
negatively
regulated
NOS2A
, which is induced
in human glioblastoma
(Broholm et al.,
2003)
AK042766
5kb from
Meis1
are correlated with
Meis1
, which is lowered
in expression in RLS
Restless Legs Syndrome
(RLS)
(Ponjavic et al.,
2009)
DISC2
Antisense
to
protein-coding
gene DISC1
Disruption of
DISC
genomic loci is linked
to many psychiatric
diseases
schizophrenia,
schizoaffective disorder,
bipolar disorder, major
depression, and autistic
spectrum disorders
(Chubb et al.,
2008; Millar et al.,
2000; Williams et
al., 2009)