8 - IJMZ-v4n2页

Legume Genomics and Genetics 2014, Vol. 5, No. 1, 1-3
http://cmb.biopublisher.ca
5
Table 1 lncRNAs involved in brain and CNS development and the resulting phenotypes in model animal systems
lncRNA Process Phenotype Reference(s)
Dlx1os Homeodomain transcription
factor regulation in developing
brain
Morphologically normal together with mild
skull and neurological defects by gene
inactivation
(Kraus et al.,
2013)
Dlx6os1 Homeodomain transcription
factor regulation in developing
brain
Morphologically normal together with altered
GABAergic interneuron development by
gene inactivation
(Feng et al.,
2006)
Malat1 Tumorigenesis Normal animal development by gene
inactivation
(Zhang et al.,
2012)
Miat Retina development Defects in specification of retina cell types by
knockdown and overexpression in neonatal
retina
(Rapicavoli et al.,
2010)
Six3os1 Retina development Defects in specification of retina cell types by
knockdown and overexpression in neonatal
retina
(Rapicavoli et al.,
2011)
Tug1 Retina development Defects in differentiation of photoreceptor
progenitor cells after knockdown in neonatal
retina
(Young et al.,
2005)
RNCR2 Retina development Knockdown leads to the increase of amacrine
cells and Müller glial cells in post-natal retina
(Rapicavoli et al.,
2010)
Vax2os Retina development Defects in differentiation of photoreceptor
progenitor cells after overexpression in
neonatal retina
(Meola et al.,
2012)
Note: Long non-coding RNAs: new players in cell differentiation and development
Table 2 lncRNAs involved in diseases of the CNS
lncRNA Genomics Evidence Disease Reference(s)
Ube3a-as Antisense to Ube3a responsible for repressing
paternal Ube3a ex-
pression; silencing of
paternal Ube3a can
occur in the absence of
Ube3a-as
PWS-AS (Vitali et al.,
2010)
FMR4 share a bidirectional
promoter with the
FMR1 gene
is silenced in FXS;
FMR4 does not simply
regulate FMR1
FXS (Khalil et al.,
2008)
ASFMR1 antisense to the 5′
UTR region of FMR1
is silenced in FXS FXS (Ladd et al., 2007)
Sox2OT encompasses the
entire Sox2 gene
implicated in modulating
Sox2 expression
CNS developmental
abnormalities
(Amaral et al.,
2009)
A region in
2q11.2
2q11.2
chromosomal
region that includes
DGCR5, a REST
regulated lncRNA
VCFS is caused by
deletions of the region
velocardiofacial
syndrome (VCFS)
(Johnson et al.,
2009)
NRON mediates the cyto-
plasmic to nuclear
shuttling of the NFAT
NRON is potentially
associated with DS
through NFAT
Down's syndrome (DS) (Arron et al.,
2006)