Cancer Genetics and Epigenetics 2017, Vol.5, No.4, 17-24
23
3 Conclusion
We describe a rare case of WHO Grade III anaplastic ependymoma in CPA region. Cerebellopontine angle (CPA)
lesions can mimic more common tumors through nonspecific symptoms and radiologic findings. Conventional
MRI sequences (T1- and T2-weighted MRI, contrast T1-weighted MRI) and information on lesion intensity, size,
shape, boundary, multi-lobular growth, and surrounding edema) have not identified any pathognomonic radiologic
features for the diagnosis of this entity; MR-spectroscopy provides additional biochemical information in which
intense signals of myo-inositol are observed in ependymomas. However, due to the rarity of this entity, an
accurate preoperative diagnosis remains difficult. This report documents a case of CPA anaplastic ependymoma
and is contributory to understanding this rare neoplasm.
Authors’ contributions
Liang Zong-hui conceived and designed the work that led to the submission. Dou Ya-fang and Liang Zong-hui evaluated images and
analyzed data. Dou Ya-fang completed the writing of the article. Liang Zong-hui revised the paper. All authors participated in paper
writing and approved the final manuscript.
Acknowledgments
This work was supported by the Shanghai Jing’an District Health System talent training Plan discipline leader, project number
JWRC2014D04.
Reference
Chen R., et al., 2017, Glioma Subclassifications and Their Clinical Significance, Neurotherapeutics, 14(2):284-297
PMid: 28281173
Cosgrove G.R., et al., 1985, Extraaxial ependymoma of the posterior fossa. Surg Neurol, 24(4):433-436
Donich D., Lee J.H., and Prayson R., 1999, Giant extra-axial cerebellopontine angle/cavernous sinus ependymoma: case report, Neurosurgery, 44(1):195-198
PMid: 9894981
Ferris S.P., et al., 2017, Characterization of gliomas: from morphology to molecules, Virchows Arch
PMid: 28674742
Fukui M.B., Hogg J.P., and Martinez A.J., 1997, Extraaxial ependymoma of the posterior fossa, AJNR Am J Neuroradiol, 18(6):1179-1181
Gill A.S., et al., 2015, Extra-axial ependymoma presenting as a cerebellopontine angle mass, Otol Neurotol, 36:138-139
PMid: 24914791
Goto T., et al., 2003, Extra-axial subarachnoid ependymoma of the cerebral convexity, Acta Neurochir (Wien), 145(10):913-917
PMid: 14577014
Hanchey R.E., et al., 1976, Interhemispheric ependymoma mimicking falx meningioma, Case report, J Neurosurg, 45(1):108-112
PMid: 932791
Hayashi K., et al., 1994, Extra-axial ependymoma--case report. Neurol Med Chir (Tokyo), 34(5):295-299
Kasliwal M.K., Chandra P.S., and Sharma B.S., 2007, Images in neuro oncology: primary extraaxial cerebellopontine angle ependymoma, J Neurooncol,
83(1):31-32
PMid: 17396227
Ma, L., et al., 2012, Intracranial extraaxial ependymoma in children: a rare case report and review of the literature, Neurol Sci, 33(1):151-154
PMid: 21710127
Marsecano C., et al., 2017, Systemic metastases from central nervous system ependymoma: case report and review of the literature, Neuroradiol J,
30(3):274-280
PMid: 28627990
Park E.K., et al., 2010, 17-year-old girl with headache and complex partial seizure, Brain Pathol, 20(6):1111-1114
