 
          Cancer Genetics and Epigenetics 2017, Vol.5, No.1, 1
        
        
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          4
        
        
          widely used in clinical practice. Pertuzumab add to Trastuzumab andpaclitaxel is the first-line treatment of
        
        
          metastatic breast cancer to Her - 2 positive patients (Swain et al., 2014).
        
        
          Acknowledgment
        
        
          This work was supported by the Science Innovation Project (201613) and Special Fund for Excellent Academic Leader of Harbin
        
        
          (2015RAXYJ051).
        
        
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