Cancer Genetics and Epigenetics 2017, Vol.5, No.1, 1
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5
1
Review and Progress Open Access
The Diagnosis and Treatment of Breast Invasive Lobular Carcinoma
Li W.Q.
1
, Zhai Z.W.
1
, Guo Z.F.
1
, Zhang D.W.
1,2
1 The Second Hospital of Harbin Medical University, Harbin, 150081, China
2 Heilongjiang Academy of Medical Sciences, Harbin, 150081, China
Corresponding author Email:
Cancer Genetics and Epigenetics, 2017, Vol.5, No.1 doi
Received: 4 Jan., 2017
Accepted: 5 Jan., 2017
Published: 5 Jan., 2017
Copyright © 2016
Li et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article
:
Li W.Q., Zhai Z.W., Guo Z.F., and Zhang D.W., 2017, The diagnosis and treatment of breast invasive lobular carcinoma, Cancer Genetics and Epigenetics, 5(1):
1-5 (doi
Abstract
Invasive lobular carcinoma of the breast to breast cancer cells in the breakthrough of mammary gland flocculus endings
tube or to lobular acini basement membrane mesenchymal invasive growth as the main characteristics.Breast invasive lobular
carcinoma usually has a better prognosis of phenotype, low-level histological grade, low mitotic index, hormone
receptor-positive,its her-2 negative, P53, low, lack of calcium mucin, sensitivity to endocrine therapy.Tended to be older patients
diagnosis, tumor larger, axillary lymph node metastasis rate is higher, when a side breast invasive lobular carcinoma, the contralateral
tend to occur.Invasive lobular carcinoma invasive is strong, has extensive transfer value tendency, therefore, in some studies in
comparison with other invasive carcinoma with poor prognosis.
Keywords
Invasive lobular carcinoma; Immunohistochemistry and molecular biology; Comprehensive treatmen
ILC usually shows the unique morphology,pathology and molecular,and the tend of the incedence is increasing
year by year. Breast invasive lobular carcinoma was reviewed in this article, in which including the clinical
manifestation, auxiliary examination, pathological characteristics, molecular, comprehensive treatment, the latest
progress of these sides.
Epidemiology
Breast cancer is a heterogeneous disease, which has more than 30 kinds of tissue types. The infiltrating ductal
carcinoma (invasive ductal carcinoma, IDC) accounted for 60% 70%, invasive lobular carcinoma is the second
common type of invasive cancer, 5% ~ 15% (Reed et al., 2015). of the invasive breast cancer , just less than the
infiltrating ductal carcinoma. The peaks of the Invasive lobular carcinoma is in 50 ~ 60 postmenopausal women,
the infiltrating ductal carcinoma is higher 1 ~ 3 years old on average, and some patients are under 40 years old
(Oliveira et al., 2014).
Clinical Manifestation
The clinical feature of invasive lobular carcinoma is specific bump, but sometimes which lack of clear boundary,
and the bump is a little greater than patients with IDC. The bump of 5cm is common. Lymph nodes change: It is
always late when the patients with tumor were found, and the lymph node metastasis rate is higher. Viscera
metastas: The transfer ways of Invasive lobular carcinoma and infiltrating ductal carcinoma are different. The
latter is common in the lung, liver and brain metastasis. Lobular carcinoma is easy to transfer to the surface of pia
mater, peritoneal and retroperitoneal areas, such as the gastrointestinal tract, reproductive organs and bone (Li and
Li, 2012).
Auxiliary Examination
Imaging change: Maybe diffuse invasive growth and the most of the type of glandular or high density mammary
gland, Mammography in the diagnosis of ILC is often misdiagnosis. False negative rate is 10% higher than the
infiltrating ductal carcinoma, sensitivity is 57% ~ 92%, and we underestimate the size of focus. The change of ILC
in MRI is irregular lump, astral jagged edges, uneven reinforcement of mass, and there is no significant difference
