International Journal of Clinical Case Report, 2016, Vol.6, No.16, 1-4
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clinical findings, the diagnosis of Melkersson-Rosenthal syndrome (MRS), which presents with the classic triad of
facial palsy, lingua plicata and cheilitis granulomatosa, was given. Panoramic radiograph did not reveal any
significant findings. Complete blood count was normal. HIV/HBV tests were negative. The patient was advised
incisional biopsy on lower lip. (Figure 4) On histopathological examination, aggregates of non-caseating
epitheloid cell granulomas with multinucleated. Langerhan’s giant cells and chronic inflammatory cell infiltrates
comprising chiefly of lymphocytes were seen. (Figure 5) Based on characteristic clinical and histopathological
findings, the diagnosis of Melkersson-Rosenthal syndrome was confirmed.
Figure 1 Facial palsy in relation to left side of face with the patient being unable to close eye on left side
Figure 2 Extra-oral examination revealing diffuse swelling in relation to both the lips
Figure 3 Intra-oral examination revealing plications over the tongue
