International Journal of Clinical Case Report, 2016, Vol.6, No.16, 1-4
1
Research Report
Open Access
Title of the Manuscript: Melkersson-Rosenthal Syndrome (MRS): An Unusual
Case of an 8 Years Old Child
Swati V. Reddy
1
, Abhishek Singh Nayyar
2,
, Pradnya M. Arur
3
, Birangane R.S.
4
1 Senior Lecturer, Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital and Post-Graduate Research Institute,
Parbhani, Maharashtra, India
2 Reader, cum PG Guide, Department of Oral Medicine and Radiology, Saraswati Dhanwantari Dental College and Hospital and Post-Graduate Research
Institute, Parbhani, Maharashtra, India
3 Ex-Post-Graduate Student, Department of Oral Medicine and Radiology, Pandit Deendayal Upadhyaya Dental College and Research Center, Solapur,
Maharashtra, India
4 Professor and Head of Department, Department of Oral Medicine and Radiology, Pandit Deendayal Upadhyaya Dental College and Research Center, Solapur,
Maharashtra, India
Corresponding author email:
International Journal of Marine Science, 2016, Vol.6, No.16 doi:
Received: 20 May, 2016
Accepted: 25 May, 2016
Published: 01 Aug., 2016
Copyright
© 2016 This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article
:
Swati V.R., Abhishek S.N., Pradnya M.A., and Birangane R.S., 2016, Title of the Manuscript: Melkersson-Rosenthal Syndrome (MRS): An Unusual Case of an
8 Years Old Child, International Journal of Clinical Case Report, 6(16): 1-4 (doi:
)
Abstract
Melkersson-Rosenthal syndrome (MRS) is a clinical entity which is characterized by the classic triad of facial palsy.
Miescher’s cheilitis granulomatosa (CG) and lingua plicata. It is an intricate neuro-muco-cutaneous disorder and triad of this disorder
is very rarely seen. Majority of the patients show facial palsy and cheilitis granulomatosa (CG) and sometimes, lingua plicata.
Diagnosis of cheilitis granulomatosa is based on histopathological outlook. Herewith, we are presenting a case report of an 8 years
old, pediatric patient presenting with the classic triad of Melkersson-Rosenthal syndrome.
Keywords
Melkersson-Rosenthal syndrome (MRS)
;
Miescher’s cheilitis granulomatosa (CG)
;
facial palsy; lingua plicata
1 Introduction
Melkersson first described the findings of oro-facial edema and facial paralysis in 1928; therefore, initially, the
name Melkersson syndrome was given. In 1930, rosenthal added the finding of lingua plicata (fissured or
furrowed tongue); thereby, completing the triad which defines the syndrome. Since then, this triad is identified as
Melkersson-Rosenthal syndrome (MRS) (Gürkan et al., 2015). Miescher in 1945, described cheilitis
granulomatosa, in patients with Melkersson-Rosenthal syndrome (MRS). Complete expression of the 3 signs,
although it is rarely reported and most often, a partial expression is seen (Agarwal et al., 2011).
Melkersson-Rosenthal syndrome is an uncommon neuro-muco-cutaneous disorder. The diagnosis is based largely
on clinical and characteristic histopathological findings like non-caseating epitheloid cell granulomas,
multinucleated giant cells (Langerhan’s giant cells), chronic inflammatory cell infiltrates and significant
lymphoedema (Ozgursoy et al., 2009). The exact etiology and pathogenesis of Melkersson-Rosenthal syndrome,
however is unknown. It is usually seen in 2nd and 3rd decades of life. Herewith, we are presenting a case report of
an 8 years old, pediatric patient presenting with the classic triad of Melkersson-Rosenthal syndrome.
1.1 Case Report
An 8 years old male child reported with a chief complaint of swelling in relation to lower lip since 15 days. The
swelling was smaller in size initially and had gradually progressed to the present size. There was no history of
trauma or infection or any drug intake in the past for similar reason. On general physical examination, the patient
was moderately built and all the vital signs were found to be within normal limits. On cranial nerve examination,
facial palsy was noted in relation to left side of the face. Patient was unable to close eye on left side (Figure1), and
also on smiling, his left corner of mouth showed a characteristic drooping of the left corner of mouth. Extra-oral
examination showed diffuse swelling in relation to both the lips, (Figure 2) which was soft, non-tender and
non-fluctuant. Intra-oral examination revealed plications over the tongue. (Figure 3) On the basis of characteristic
