Molecular Pathogens, 2025, Vol.16, No.3, 111-120 http://microbescipublisher.com/index.php/mp 119 Field practice and empirical research further show that the scientific setting of non-host rotation system can significantly reduce the number of pathogens and disease index, while increasing soil enzyme activity and organic matter level, improving rhizosphere microecological environment, and thus building a stable "pathogen antagonistic" ecosystem. Rotation methods of different years and combinations have shown good disease prevention effects in typical areas such as greenhouses in North China and tropical open fields, proving the wide adaptability and practical feasibility of non-host plant rotation. In the future, we should continue to strengthen the research on regional rotation adaptability and establish a systematic prevention and control mechanism model between non-host plants and specific diseases. At the same time, explore the synergistic effect of rotation and biological control measures such as microbial agents and biochar, and take into account soil nutrient circulation and carbon sink management while achieving disease prevention. At the promotion level, non-host rotation should be included in the annual crop cultivation plan and green prevention and control strategy, and digital agricultural tools should be combined to improve the level of intelligent decision-making, so as to provide theoretical support and practical models for building a green, efficient and sustainable disease management system. Acknowledgments Heartfelt gratitude is extended to the two anonymous peer reviewers for their comprehensive evaluation of the manuscript. Conflict of Interest Disclosure The authors confirm that the study was conducted without any commercial or financial relationships and could be interpreted as a potential conflict of interest. References Adetunji A.T., Ncube B., Mulidzi R., and Lewu F.B., 2020, Management impact and benefit of cover crops on soil quality: a review, Soil and Tillage Research, 204: 104717. https://doi.org/10.1016/j.still.2020.104717 Ayana G., and Fininsa C., 2023, Effect of crop rotation on tomato bacterial wilt (Ralstonia solanacearum) and survival of the pathogen in the rhizospheres and roots of different crops in Ethiopia, International Journal of Phytopathology, 5(3): 81-88. https://doi.org/10.33687/phytopath.005.03.1932 Cai R.X., 2024, Environmental assessments of triticale cultivation: implications for crop rotation and soil health, Field Crop, 7(5): 261-269. Cha J.Y., Han S., Hong H.J., Cho H., Kim D., Kwon Y., Kwon S.K., Crüsemann M., Lee Y.B., Kim J.F., Giaever G., Nislow C., Moore B.S., Thomashow L.S., Weller D.M., and Kwak Y.S., 2016, Microbial and biochemical basis of a Fusarium wilt-suppressive soil, The ISME Journal, 10(1): 119-129. https://doi.org/10.1038/ismej.2015.95 De Corato U., Patruno L., Avella N., Salimbeni R., Lacolla G., Cucci G., and Crecchio C., 2020, Soil management under tomato-wheat rotation increases the suppressive response against Fusarium wilt and tomato shoot growth by changing the microbial composition and chemical parameters, Applied Soil Ecology, 154: 103601. https://doi.org/10.1016/j.apsoil.2020.103601 Feng C., Yi Z., Qian W., Liu H., and Jiang X., 2023, Rotations improve the diversity of rhizosphere soil bacterial communities, enzyme activities and tomato yield, PloS One, 18(1): e0270944. https://doi.org/10.1371/journal.pone.0270944 Gao D., Fang Z., Pan X., Liu S., Ullah A., Ibrahim M., Zhou X.G., Zhang Y., and Wu F., 2025, Decomposition solutions from brassica and cereal residues suppress tomato bacterial wilt disease by regulating rhizosphere microbial communities, Microbiological Research, 292: 128010. https://doi.org/10.1016/j.micres.2024.128010 Hu Y., Zhao W., Li X., Feng J., Li C., Yang X., and Yang Y., 2021, Integrated biocontrol of tobacco bacterial wilt by antagonistic bacteria and marigold, Scientific Reports, 11(1): 16360. https://doi.org/10.1038/s41598-021-95763-z Hong S., Yuan X., Yang J., Yang Y., Jv H., Li R., and Ruan Y., 2023, Selection of rhizosphere communities of diverse rotation crops reveals unique core microbiome associated with reduced banana Fusarium wilt disease, New Phytologist, 238(5): 2194-2209. https://doi.org/10.1111/nph.18816 Li Q.M., Zhang D., Zhang J.Z., Zhou Z.J., Pan Y., Yang Z.H., and Zhang L.F., 2023, Crop rotations increased soil ecosystem multifunctionality by improving keystone taxa and soil properties in potatoes, Frontiers in Microbiology, 14: 1034761. https://doi.org/10.3389/fmicb.2023.1034761
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