Molecular Pathogens 2024, Vol.15, No.4, 170-178 http://microbescipublisher.com/index.php/mp 173 Figure 2 Spatiotemporal analysis of chromosome replication in a B. bacteriovorus cell growing in a bdelloplast (Adopted from Makowski et al., 2019) Image caption: (A) Free-living predatory and host cell. (B) Attachment of B. bacteriovorus to an E. coli cell. (C) Bdelloplast formation. (D) Appearance of the first replisome focus at pilus pole of B. bacteriovorus cell-the start of chromosome replication. (E and F) Further growth and chromosome replication. (G) Termination of predatory chromosome replication. (H) The beginning of B. bacteriovorus filament septation. (E) The release of progeny cells from the bdelloplast (Adopted from Makowski et al., 2019) 4.2 Effectiveness in preclinical studies 4.2.1 In vitro studies: targeting multidrug-resistant bacteria In vitro studies have demonstrated the potential of predatory bacteria to target and kill multidrug-resistant pathogens. For instance, Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus have been shown to effectively reduce bacterial populations in controlled environments, highlighting their potential as a tool against antibiotic-resistant bacteria. These studies underline the non-cytotoxic nature of predatory bacteria on human cell lines, further supporting their safety and efficacy as therapeutic agents (Gupta et al., 2016).
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