Journal of Vaccine Research 2024, Vol.14, No.2, 40-53 http://medscipublisher.com/index.php/jvr 42 Figure 1 Protection of mice against heterologous challenge by a single immunization with nucleoside-modified mrna encoding influenza virus antigens (Adapted from Freyn et al., 2020) Image Caption: The figure shows the body weight change curves of mice 28 days after a single intradermal injection of 20 μg mRNA-LNPs (nucleoside-modified mRNA nanoparticles). Mice in different groups were exposed to 5 times the lethal dose (LD50) of the influenza virus: A) A/New Caledonia/20/1999 H1N1 virus, B) A/Puerto Rico/8/1934 H1N1 virus, C) H5N8 virus, D) cH6/1N5 virus. E summarizes the maximum weight loss in each group during the different virus challenge experiments; each group shows the mean and standard error of the mean (SEM) (Adapted from Freyn et al., 2020) Freyn et al. (2020) evaluated the protective efficacy of a nucleoside-modified mRNA-based vaccine encoding antigens from multiple influenza viruses in mice. Through a single vaccine injection, mice exhibited significant weight retention and survival rates when exposed to various influenza viruses. The experimental results demonstrated that the vaccine effectively mitigated weight loss, particularly under high-dose viral exposure. This
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