JVR_2024v14n1

Journal of Vaccine Research 2024, Vol.14, No.1, 17-26 http://medscipublisher.com/index.php/jvr 22 molecules. It's important to note that vaccine-induced immune protection is not absolute, so personal hygiene and disease prevention measures should still be observed after vaccination (Kew et al., 2005; Zhang et al., 2022) (Figure 5). Figure 5 The Immunological Process of Vaccination In the Body (Source: https://blog.sciencenet.cn/blog-347754-1285946.html) 3 Innovation and Optimization of Vaccines 3.1 Innovation and improvement of vaccine technologies With the continuous development of biotechnology and vaccine technology, vaccine preparation techniques have also been innovated and improved. In the research of polio vaccines, researchers have utilized genetic engineering techniques to insert a portion of the poliovirus's genetic sequence into a viral vector, creating a novel gene-recombinant vaccine. Compared to traditional vaccines, gene-recombinant vaccines offer better immunogenicity and safety, making them an important focus in vaccine research. By continuously innovating and improving vaccine preparation techniques and methods, researchers can enhance the immunogenicity and safety of vaccines, thereby better preventing and controlling the occurrence of infectious diseases like polio. The preparation method of gene-recombinant vaccines involves combining a portion of the virus's genetic sequence with a different viral vector, forming a recombinant virus. Compared to traditional vaccines, gene-recombinant vaccines have higher immunogenicity, which enhances their immunogenic effectiveness.

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