Journal of Vaccine Research 2024, Vol.14, No.1, 17-26 http://medscipublisher.com/index.php/jvr 20 Figure 2 Polio Live Attenuated Vaccine (Source: https://www.360zhyx.com/home-research-index-rid-72053.shtml) Figure 3 Inactivated Polio Vaccine (Source: https://yi.9939.com/76809/sms.html) It's important to note that different types of vaccines use different techniques and methods in their preparation, which can lead to variations in vaccine effectiveness and safety. For example, the preparation process of inactivated vaccines may alter the antigenicity of the virus, affecting their immunogenicity. Therefore, when choosing a vaccine type, it's necessary to consider individual characteristics and follow a doctor's advice. The classification and characteristics of polio vaccines are significant for the prevention and control of polio. Both live attenuated and inactivated vaccines have their advantages and disadvantages, and the choice of vaccine type should be based on individual circumstances. It's essential to follow a doctor's recommendations during the vaccination process and be aware of vaccine side effects and contraindications to ensure the safety and effectiveness of vaccination (Chen et al., 2021). 2.2 Antigens and preparation methods of vaccines The process of preparing inactivated polio vaccines involves cultivating the poliovirus in cell cultures, and then using chemical substances or thermodynamic methods to inactivate the virus, ultimately producing the inactivated vaccine. During the preparation of inactivated vaccines, it is essential to ensure the integrity and stability of the virus while also ensuring that the inactivation process does not affect the virus's immunogenicity. The preparation method of live vaccines: The preparation method of live vaccines is relatively complex and requires multiple passages to gradually lose their virulence, ultimately leading to the preparation of live vaccines. During the preparation process, it is crucial to pay attention to the number of passages and cultivation conditions of the virus to ensure both its stability and immunogenicity (Figure 4).
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