IJMMS_2025v15n5

International Journal of Molecular Medical Science, 2025, Vol.15, No.5, 244-252 http://medscipublisher.com/index.php/ijccr 252 Xuan J., 2024, Innovative antiviral strategy targeting PLpro: discovery of Jun12682 and analysis of its antipandemic effects, International Journal of Molecular Medical Science, 14(1): 56-60. https://doi.org/10.5376/ijmms.2024.14.0008 Xu S., Gao Y., Zhang Q., Wei S., Chen Z., Dai X., Zeng Z., and Zhao K., 2016, SIRT1/3 activation by resveratrol attenuates acute kidney injury in a septic rat model, Oxidative Medicine and Cellular Longevity, 2016(1): 7296092. https://doi.org/10.1155/2016/7296092 Xu Y., Zhang S., Rong J., Lin Y., Du L., Wang Y., and Zhang Z., 2020, Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle, Pharmacological Research, 159: 104887. https://doi.org/10.1016/j.phrs.2020.104887 You J., Li Y., and Chong W., 2024, The role and therapeutic potential of SIRTs in sepsis, Frontiers in immunology, 15: 1394925. https://doi.org/10.3389/fimmu.2024.1394925 Yu H., Liu Q., Chen G., Huang L., Luo M., Lv D., and Luo S., 2022, SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis, International Immunopharmacology, 106: 108600. https://doi.org/10.1016/j.intimp.2022.108600 Zhang W., Jiang H., Wu G., Huang P., Wang H., An H., Liu S., and Zhang W., 2023, The pathogenesis and potential therapeutic targets in sepsis, MedComm., 4(6): e418. https://doi.org/10.1002/mco2.418 Zhou C., Zhang Y., Jiao X., Wang G., Wang R., and Wu Y., 2020, SIRT3 alleviates neuropathic pain by deacetylating FoxO3a in the spinal dorsal horn of diabetic model rats, Regional Anesthesia and Pain Medicine, 46: 49-56. https://doi.org/10.1136/rapm-2020-101918 Zou Z., Liu B., Zeng L., Yang X., Huang R., Wu C., Zhu H., Gao Y., Yuan D., and Yu J., 2019, Cx43 inhibition attenuates sepsis-induced intestinal injury via downregulating ROS transfer and the activation of the JNK1/Sirt1/FoxO3a signaling pathway, Mediators of Inflammation, 2019(1): 7854389. https://doi.org/10.1155/2019/7854389 Zhou J.R., 2024 Targeted therapy for specific genetic variations in cancer, International Journal of Clinical Case Reports, 14(2): 79-86. https://doi.org/10.5376/ijccr.2024.14.0010 Zhou T.Y., Wu Y.G., Zhang Y.Z., Bao Y.W., and Zhao Y., 2019, SIRT3 retards intervertebral disc degeneration by anti-oxidative stress by activating the SIRT3/FOXO3/SOD2 signaling pathway, European Review for Medical and Pharmacological Sciences, 23(21): 9180-9188. https://doi.org/10.26355/eurrev_201911_19408

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