International Journal of Molecular Medical Science, 2025, Vol.15, No.4, 195-204 http://medscipublisher.com/index.php/ijmms 195 Feature Review Open Access Role of Early Hemostasis Nursing and Coagulation Monitoring in Multiple Trauma Cases Jiahui Zhu Zhuji Tongji Hospital, Zhuji, 311800, Zhejiang, China Corresponding email: jiahuizhu@126.com International Journal of Molecular Medical Science, 2025, Vol.15, No.4 doi: 10.5376/ijmms.2025.15.0020 Received: 26 Jun., 2025 Accepted: 10 Aug., 2025 Published: 31 Aug., 2025 Copyright © 2025 Zhu, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Zhu J.H., 2025, Role of early hemostasis nursing and coagulation monitoring in multiple trauma cases, International Journal of Molecular Medical Science, 15(4): 195-204 (doi: 10.5376/ijmms.2025.15.0020) Abstract This study explored the causes of TIC, the patterns of physical changes, and the interaction between bleeding and coagulation issues, and also summarized the key nursing methods for rapid hemostasis. This study also introduces the application of traditional coagulation monitoring techniques such as TEG and ROTEM, as well as dynamic coagulation monitoring techniques, in guiding personalized and targeted treatments. Early nurse-led intervention measures, including organized resuscitation plans and multidisciplinary collaboration, can significantly reduce the risk of death and improve clinical treatment outcomes. This study also analyzed the existing problems, such as the lack of a unified coagulation assessment method, which restricts the autonomous implementation of nursing work. The future development direction emphasizes the use of artificial intelligence to assist in monitoring, integrate interdisciplinary nursing models, make nursing work more scientific, and improve the level of trauma care services. Keywords Multiple trauma; Hemostasis nursing; Coagulation monitoring; Trauma-induced coagulopathy (TIC); Goal-directed therapy 1 Introduction Multiple trauma is the leading cause of death and disability worldwide, especially before the age of 40, making it an important public health issue in all countries. Traffic accidents are the main cause, and men are particularly affected. The high mortality rate and high morbidity caused by multiple traumas are largely due to excessive bleeding leading to shock and subsequent organ failure, which indicates the urgent need for effective early treatment methods (Raffee et al., 2020; Karim et al., 2023). Uncontrolled post-traumatic bleeding is the main cause of avoidable death in trauma patients. Many trauma patients experience abnormal coagulation function, which complicates the treatment outcome and is a major factor leading to early death in patients (Vyshynska, 2023). This coagulation problem is caused by a variety of factors, including tissue damage, shock, insufficient blood supply, acidosis, hypothermia and blood dilution, all of which can disrupt the normal coagulation process (Lier et al., 2009; Phillips et al., 2017). It is crucial to detect and solve abnormal coagulation function as early as possible, because untimely intervention may require more blood transfusion for patients, prolong hospital stay, and increase the risk of death (Raffee et al., 2020). Therefore, effective control of bleeding and proper hemostasis treatment are of great significance for improving the survival rate of patients with multiple trauma and reducing complications (Phillips et al., 2017; Fries et al., 2002). This study will explore that the coagulation problem caused by trauma remains a major challenge. Early hemostasis care and coagulation monitoring play a key role in the recovery outcome of patients. Combining coagulation monitoring at the nursing site with personalized and targeted treatment is expected to enable rapid diagnosis of the condition and the adoption of targeted intervention measures. This may reduce the demand for blood products and lead to better clinical treatment outcomes. The purpose of this review is to integrate the current clinical significance of early hemostasis care and the relevant evidence on the application of coagulation monitoring in the management of multiple traumas, identify the best care methods, and clarify the directions for future research and clinical improvement.
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