International Journal of Molecular Medical Science, 2025, Vol.15, No.2, 98-106 http://medscipublisher.com/index.php/ijmms 98 Feature Review Open Access The Study on the Impact of the Ingredient Ratio of Compound Dietary Fiber Preparations on Gut Microecological Regulation Function Huixian Li, Jingqiang Wang Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China Corresponding author: jingqiang.wang@jicat.org International Journal of Molecular Medical Science, 2025, Vol.15, No.2 doi: 10.5376/ijmms.2025.15.0010 Received: 26 Feb., 2025 Accepted: 04 Apr., 2025 Published: 25 Apr., 2025 Copyright © 2025 Li and Wang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Li H.X., and Wang J.Q., 2025, The study on the impact of the ingredient ratio of compound dietary fiber preparations on gut microecological regulation function, International Journal of Molecular Medical Science, 15(2): 98-106 (doi: 10.5376/ijmms.2025.15.0010) Abstract This study will explore the effects of different ratios of soluble fiber (SDF) and insoluble fiber (IDF) in compound dietary fiber preparations on the structure and function of the intestinal flora. The gut microbiota plays a key role in nutritional metabolism, immune regulation and the generation of short-chain fatty acids (SCFAs). Research has found that by adjusting the SDF/IDF ratio, the quantity of probiotics and the production of SCFAs can be altered, thereby promoting intestinal health and reducing inflammation. Compound fiber preparations can not only promote the growth of beneficial bacteria such as Bifidobacteriumand Lactobacillus, but also inhibit harmful bacteria such as Enterococcus and Clostridium perfringens, thereby maintaining the balance of the flora. This study also explored the impact of dietary fiber ratios on host metabolism and the role of long-term fiber intervention in the prevention of chronic diseases. Developing personalized fiber formulas can optimize intestinal health based on individual differences and provide effective dietary intervention strategies for obesity, diabetes, inflammatory bowel disease, etc. Keywords Compound dietary fiber; Gut microbiota; Short-chain fatty acids; Microbial regulation; Personalized nutrition 1 Introduction The microbiota in the intestines is very important for maintaining good health. They help complete tasks such as digestion, disease resistance and changes in substances within the body. The number and types of these flora are related to the generation of short-chain fatty acids (SCFAs), which are crucial for intestinal and overall health (So et al., 2018; Vinelli et al., 2022). If the intestinal flora is disrupted, it may cause long-term diseases such as obesity, diabetes and intestinal inflammation (Cronin et al., 2021). Keeping the microbiota in a stable state is the foundation for preventing illness. Mixed dietary fiber products contain two types of fiber: soluble and insoluble, which have different effects on the intestines. Soluble fiber can promote the production of short-chain fatty acids such as acetic acid and propionic acid. These substances can protect the intestinal barrier and reduce inflammation (Zhai et al., 2018; Liu et al., 2021). Insoluble fiber can help normal intestinal peristalsis and increase the types of flora at the same time (Lin et al., 2021; Zhang et al., 2023). The mixing ratio of the two fibers will significantly affect their effects in regulating the microbiota and metabolic processes (Li et al., 2023; Zhang et al., 2023). This study will explore the influence of different soluble/insoluble fiber ratios on the intestinal flora. It is very important to clarify this relationship, which can help develop dietary plans that improve intestinal function. Meanwhile, the mechanism of action between fiber and microbiota is studied to provide a reference for the design of supplements that enhance intestinal health and metabolism. By exploring personalized dietary plans, this study hopes to provide new guiding methods for health management. 2 Intestinal Microbiota and Health 2.1 Composition of the intestinal flora: beneficial bacteria, pathogenic bacteria and their functions The intestinal microbiota is a group of microorganisms living in the intestines and is crucial for maintaining human health. It is mainly composed of two major categories: Bacteroides and thick-walled bacteria. They help process nutrients, regulate immunity and resist harmful bacteria (Sekirov et al., 2010; Jandhyala et al., 2015). "Good bacteria" like Bifidobacterium can break down dietary fiber to produce short-chain fatty acids. Such
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