International Journal of Molecular Medical Science, 2024, Vol.14, No.6, 380-392 http://medscipublisher.com/index.php/ijmms 380 Research Article Open Access Study on Individualized Dietary Therapy for Diabetes Based on Traditional Chinese Medicine (TCM) Constitution Identification JingZhang1, Yeli Huang2 , Xiaolei Qi 3 1 Department of Traditional Chinese Medicine, The Sixth Medical Center of the People's Liberation Army General Hospital, Beijing, 100048, Beijing, China 2 People's Liberation Army General Hospital, Beijing, 100853, , Beijing, China 3 Nursing Department, The Sixth Medical Center of the People's Liberation Army General Hospital, , Beijing, 100048, Beijing, China Corresponding author: huangyeli88@163.com International Journal of Molecular Medical Science, 2024, Vol.14, No.6 doi: 10.5376/ijmms.2024.14.0037 Received: 26 Oct., 2024 Accepted: 29 Nov., 2024 Published: 15 Dec., 2024 Copyright © 2024 Chen and Zhang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Zhang J., Huang Y.L., and Qi X.L., 2024, Study on individualized dietary therapy for diabetes based on traditional Chinese medicine (TCM) constitution identification, International Journal of Molecular Medical Science, 14(6): 380-392 (doi: 10.5376/ijmms.2024.14.0037) Abstract Individualized dietary therapy based on Traditional Chinese Medicine (TCM) constitution identification has emerged as a promising approach for managing diabetes. This review article synthesizes current research on the theory and practice of TCM constitution-based dietary interventions for diabetes. The evidence suggests that TCM-based lifestyle modifications, including specific dietary regimens tailored to individual TCM constitutions, can significantly improve glycemic control and overall health outcomes in diabetic patients. Studies have demonstrated that interventions such as tai chi and ba duan jin can lower glycosylated hemoglobin and fasting blood glucose levels, while TCM herbal formulations combined with conventional Western medicine show enhanced efficacy in managing type 2 diabetes mellitus (T2DM) and its complications. Furthermore, the identification of TCM constitution types, such as yin-deficiency and phlegm-dampness, provides a framework for personalized dietary recommendations that may mitigate diabetes risk and progression. Despite these promising findings, further well-designed, large-scale studies are needed to validate the long-term benefits and optimize the application of TCM constitution-based dietary therapy in diabetes management. Keywords Traditional Chinese medicine (TCM); Diabetes mellitus; Dietary therapy; TCM constitution; Glycemic control 1 Introduction Diabetes mellitus (DM) is one of the most severe public health problems globally, affecting nearly 463 million adults (Lian et al., 2020). The prevalence of type 2 diabetes mellitus (T2DM) has been rising steadily, posing significant challenges to healthcare systems worldwide (Li et al., 2022). Despite advancements in conventional diabetes therapies, such as insulin and oral hypoglycemic agents, these treatments often come with severe side effects and do not fully meet the complex clinical needs of patients (Wang et al., 2022). Additionally, the management of diabetes is complicated by its chronic nature and the need for long-term medication adherence, lifestyle modifications, and monitoring of blood glucose levels (Chen et al., 2023). The increasing incidence of diabetic complications, such as cardiovascular diseases and diabetic wounds, further exacerbates the burden on patients and healthcare providers (Zhou et al., 2021). Traditional Chinese Medicine (TCM) offers a unique perspective on the treatment of diabetes, emphasizing the importance of individualized therapy based on TCM constitution identification (Wang et al., 2023). TCM has a long history of managing diabetes, known as "Xiao Ke" disease, through various herbal formulations, acupuncture, and lifestyle interventions (Zheng et al., 2019). The TCM constitution-based approach differentiates individuals based on their physical signs, personality, body symptoms, and susceptibility to environmental changes, allowing for more personalized and effective treatment plans (Wang et al., 2023). Studies have shown that TCM interventions, such as tai chi and ba duan jin, can significantly improve glycemic control, reduce body mass index, and enhance the quality of life in individuals with T2DM (Yu et al., 2018). Moreover, bioactive metabolites derived from TCM herbs have demonstrated promising therapeutic effects on diabetes, with fewer adverse reactions compared to conventional drugs (Li et al., 2022). This study provides a comprehensive overview of the current research on individualized dietary therapy for diabetes based on TCM constitution identification. By synthesizing evidence from various studies, this study
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