IJMMS_2024v14n5

1 Introduction	4
1 Introduction	14
1 Introduction	33
1 Introduction	45
2 KRAS Gene and Its Role in Cancer	46
2.1 Structure and function of the KRAS gene	46
2.2 Mechanisms of KRAS activation in cancer	46
2.3 Common KRAS mutations in pancreatic cancer	46
3 Genomic Mechanisms of KRAS Mutations in Pancreat	46
3.1 Molecular pathways affected by KRAS mutations	46
3.2 Interaction with other oncogenes and tumor sup	46
3.3 Impact on cellular processes	47
4 Detection and Analysis of KRAS Mutations	47
4.1 Techniques for detecting KRAS mutations	47
4.2 Diagnostic significance and prognostic value	47
4.3 Case study: application of KRAS mutation analy	47
5 Therapeutic Implications of KRAS Mutations	47
5.1 Current treatment strategies targeting KRAS mu	47
5.2 Challenges in developing KRAS-targeted therapi	48
5.3 Emerging therapies and clinical trials	49
5.4 Case study: success and challenges of specific	49
6 Resistance Mechanisms and Overcoming Challenges	49
6.1 Mechanisms of resistance to KRAS-targeted ther	49
6.2 Combination therapies and novel approaches	49
6.3 Case study: overcoming resistance in pancreati	49
7 Future Directions and Perspectives	51
7.1 Advances in genomic technologies for better un	51
7.2 Potential biomarkers for predicting therapy re	51
7.3 Personalized medicine approaches for KRAS-Muta	52
1 Introduction	55

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