IJMMS_2024v14n5

International Journal of Molecular Medical Science, 2024, Vol.14, No.5, 315-323 http://medscipublisher.com/index.php/ijmms 322 Chang W., Thissen U., Ehlert K., Koek M., Jellema R., Hankemeier T., Greef J., and Wang M., 2006, Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy, Planta Medica, 72(5): 458-467. https://doi.org/10.1055/S-2005-916241 Feng J., Cai Z., Zhang X., Chen Y., Chang X., Wang X., Qin C., Yan X., Ma X., Zhang J., and Nie G., 2020, The effects of oral Rehmannia glutinosa polysaccharide administration on immune responses, antioxidant activity and resistance against aeromonas hydrophila in the common carp, Cyprinus carpio L., Frontiers in Immunology, 11: 904. https://doi.org/10.3389/fimmu.2020.00904 Gong W., Zhang N., Cheng G., Zhang Q., He Y., Shen Y., Zhang Q., Zhu B., Zhang Q., and Qin L., 2019, Rehmannia glutinosa libosch extracts prevent bone loss and architectural deterioration and enhance osteoblastic bone formation by regulating the IGF-1/PI3K/mTOR pathway in streptozotocin-induced diabetic rats, International Journal of Molecular Sciences, 20(16): 3964. https://doi.org/10.3390/ijms20163964 Han K., Bose S., Kim Y., Chin Y., Kim B., Wang J., Lee J., and Kim H., 2015, Rehmannia glutinosa reduced waist circumferences of Korean obese women possibly through modulation of gut microbiota, Food & Function, 6(8): 2684-2692 . https://doi.org/10.1039/c5fo00232j Hsu P., Tsai Y., Lai J., Wu C., Lin S., and Huang C., 2014, Integrating traditional Chinese medicine healthcare into diabetes care by reducing the risk of developing kidney failure among type 2 diabetic patients: a population-based case control study, Journal of Ethnopharmacology, 156: 358-364. https://doi.org/10.1016/j.jep.2014.08.029 Huang Y., Ando H., Tsujino M., Yoshihara K., Zhang L., and Sasaki Y., 2022, Study on catalpol content in rehmannia glutinosa root, an important ingredient in kampo prescriptions, Biological & Pharmaceutical Bulletin, 45(7): 955-961 . https://doi.org/10.1248/bpb.b21-01095 Huang Y., Jiang C., Hu Y., Zhao X., Shi C., Yu Y., Liu C., Tao Y., Pan H., Feng Y., Liu J., Wu Y., and Wang D., 2013, Immunoenhancement effect of Rehmannia glutinosa polysaccharide on lymphocyte proliferation and dendritic cell, Carbohydrate Polymers, 96(2): 516-521 . https://doi.org/10.1016/j.carbpol.2013.04.018 Huang Z., Gong J., Lin W., Feng Z., Ma Y., Tu Y., Cai X., Liu J., Lv C., Lv X., Wu Q., Lu W., Zhao J., Ying Y., Li S., Ni W., and Chen H., 2022, Catalpol as a component of Rehmannia glutinosa protects spinal cord injury by inhibiting endoplasmic reticulum stress-mediated neuronal apoptosis, Frontiers in Pharmacology, 13: 860757. https://doi.org/10.3389/fphar.2022.860757 Jiao Z., Cheng Y., Wang H., Lei C., Wang G., and Han L., 2015, Isolation and characterization of microsatellite loci in Rehmannia glutinosa (Scrophulariaceae), a medicinal herb, Applications in Plant Sciences, 3(10): 1500054. https://doi.org/10.3732/apps.1500054 Kim Y., Komakech R., Jeong D., Park Y., Lee T., Kim K., Lee A., Moon B., and Kang Y., 2020, Verification of the field productivity of Rehmannia glutinosa (Gaertn.) DC. developed through optimized in vitro culture method, Plants, 9(3): 317. https://doi.org/10.3390/plants9030317 Kwak M., Yu K., Lee P., and Jin J., 2018, Rehmannia glutinosa polysaccharide functions as a mucosal adjuvant to induce dendritic cell activation in mediastinal lymph node, International Journal of Biological Macromolecules, 120: 1618-1623 . https://doi.org/10.1016/j.ijbiomac.2018.09.187 Kwon Y., Yu S., Choi G., Kim J., Baik M., Su S., and Kim W., 2019, Puffing of Rehmannia glutinosa enhances anti-oxidant capacity and down-regulates IL-6 production in RAW 264.7 cells, Food Science and Biotechnology, 28: 1235-1240. https://doi.org/10.1007/s10068-019-00566-z Lee B., Shim I., Lee H., and Hahm D., 2011, Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats, Journal of Microbiology and Biotechnology, 21(8): 874-883 . https://doi.org/10.4014/JMB.1104.04012 Lim D., and Kim Y., 2013, Dried root of Rehmannia glutinosa prevents bone loss in ovariectomized rats, Molecules, 18: 5804-5813. https://doi.org/10.3390/molecules18055804 Liu C., Cheng L., Ko C., Wong C., Cheng W., Cheung D., Leung P., Fung K., and Lau C., 2012, Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosa and its underlying mechanism via inhibition of iNOS pathway, Journal of Ethnopharmacology, 143(3): 867-875 . https://doi.org/10.1016/j.jep.2012.08.012 Liu W., Yin D., Zhang T., Qiao Q., Yang Y., and Wang W., 2020, Phytochemical profiles and antioxidant activity of Rehmannia glutinosa from different production locations, Chemistry & Biodiversity, 17(8): e2000341. https://doi.org/10.1002/cbdv.202000341 Manivannan A., Soundararajan P., Halimah N., Ko C., and Jeong B., 2015, Blue LED light enhances growth, phytochemical contents, and antioxidant enzyme activities of Rehmannia glutinosa cultured in vitro, Horticulture, Environment, and Biotechnology, 56: 105-113. https://doi.org/10.1007/s13580-015-0114-1 Nguyen H., Dan T., Uto T., Ohta T., Watanabe H., and Shoyama Y., 2020, Phytochemical profile of the aerial parts of Rehmannia glutinosa liboschitz var. purpurea Makino, Pharmacognosy Magazine, 16: 128-131. https://doi.org/10.4103/pm.pm_243_19

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