International Journal of Molecular Medical Science, 2024, Vol.14, No.5, 274-292 http://medscipublisher.com/index.php/ijmms 286 Acknowledgments The authors extend sincere thanks to two anonymous peer reviewers for their feedback on the manuscript of this study. Funding This research was funded by Natural Science Foundation of Shandong Province (ZR2023QC028). Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. 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