IJMMS_2024v14n4

International Journal of Molecular Medical Science, 2024, Vol.14, No.4, 239-251 http://medscipublisher.com/index.php/ijmms 251 Stintzing S., Tejpar S., Gibbs P., Thiebach L., Lenz H.J., 2017, Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes, European Journal Cancer, 84:69-80. https://doi.org/10.1016/j.ejca.2017.07.016 Tan Z., Kan C., Sun M., Yang F., Wong M., Wang S., and Zheng H., 2022, Mapping breast cancer microenvironment through single-cell omics, Frontiers in Immunology, 13: 868813. Wang Q., Wang Z., Zhang Z., Zhang W., Zhang M., Shen Z., Ye Y., Jiang K., and Wang S., 2020, Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing, Chinese Journal of Cancer Research, 33: 271-288. https://doi.org/10.21147/j.issn.1000-9604.2021.02.13 PMid:34158745 PMCid:PMC8181874 Winterhoff B., Maile M., Mitra A., Sebe A., Bazzaro M., Geller M., Abrahante J., Klein M., Hellweg R., Mullany S., Beckman K., Daniel J., and Starr T., 2017, Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells, Gynecologic Oncology, 144(3): 598-606. https://doi.org/10.1016/j.ygyno.2017.01.015 Wu F., Fan J., He Y., Xiong A., Yu J., Li Y., Zhang Y., Zhao W., Zhou F., Li W., Zhang J., Zhang X., Qiao M., Gao G., Chen S., Chen X., Li X., Hou L., Wu C., Su C., Ren S., Odenthal M., Buettner R., Fang N., and Zhou C., 2021, Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer, Nature Communications, 12(1): 2540. https://doi.org/10.1038/s41467-021-22801-0 Xiang R., Fu J., Ge Y., Ren J., Song W., and Fu T., 2021, Identification of subtypes and a prognostic gene signature in colon cancer using cell differentiation trajectories, Frontiers in Cell and Developmental Biology, 9: 705537. https://doi.org/10.3389/fcell.2021.705537 Yu L., Wang X., Mu Q., Tam S., Loi D., Chan A., Poon W., Ng H., Chan D., Wang J., and Wu A., 2023, scONE-seq: A single-cell multi-omics method enables simultaneous dissection of phenotype and genotype heterogeneity from frozen tumors, Science Advances, 9(1): eabp8901. https://doi.org/10.1126/sciadv.abp8901 PMid:36598983 PMCid:PMC9812385 Zhang Q., Liu Y., Wang X., Zhang C., Hou M., and Liu Y., 2023, Integration of single-cell RNA sequencing and bulk RNA transcriptome sequencing reveals a heterogeneous immune landscape and pivotal cell subpopulations associated with colorectal cancer prognosis, Frontiers in Immunology, 14: 1184167. https://doi.org/10.3389/fimmu.2023.1184167 PMid:37675100 PMCid:PMC10477986 Zhu J., Lian J., Xu B., Pang X., Ji S., Zhao Y., Lu H., 2023, Neoadjuvant immunotherapy for colorectal cancer: right regimens, right patients, right directions?, Frontiers in Immunology, 14: 1120684. https://doi.org/10.3389/fimmu.2023.1120684 PMid:36949951 PMCid:PMC10026962

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