IJMMS_2024v14n3

International Journal of Molecular Medical Science, 2024, Vol.14, No.3, 177-192 http://medscipublisher.com/index.php/ijmms 191 Montgomery R., Stern J., Lonze B., Tatapudi V., Mangiola M., Wu M., Weldon E., Lawson N., Deterville C., Dieter R., Sullivan B., Boulton G., Parent B., Piper G., Sommer P., Cawthon S., Duggan E., Ayares D., Dandro A., Fazio-Kroll A., Kokkinaki M., Burdorf L., Lorber M., Boeke J., Pass H., Keating B., Griesemer A., Ali N., Mehta S., and Stewart Z., 2022, Results of two cases of pig-to-human kidney xenotransplantation, New England Journal of Medicine, 386(20): 1889-1898. https://doi.org/10.1056/NEJMoa2120238 PMid:35584156 Niu, D., Ma, X., Yuan, T., Niu, Y., Xu, Y., Sun, Z., Ping, Y., Li, W., Zhang, J., Wang, T., and Church, G, 2020, Porcine genome engineering for xenotransplantation, Advanced Drug Delivery Reviews, 168: 229-245. https://doi.org/10.1016/j.addr.2020.04.001 PMid:32275950 Obando B., Cross-Najafi A., Lopez K., Thadasina D., Zhang W., Isidan A., Park Y., Campaña G., Li P., and Ekser B., 2021, Regulation of human NK cell activation by expression of HLA class I molecules in pig endothelial cells, Proceedings of IMPRS, 4: 1. https://doi.org/10.18060/25715 Porrett P., Cheung M., Asiimwe R., Erman E., Fucile C., Liu S., Sun C., Hanumanthu V., Pal H., Wright E., Ghajar-Rahimi G., Epstein D., Orandi B., Kumar V., Anderson D., Greene M., Bell M., Yates S., Moore K., Lafontaine J., Killian J., Baker G., Perry J., Reed R., Little S., Rosenberg A., George J., and Locke J., 2023, Spatiotemporal immune atlas of the first clinical-grade, gene-edited pig-to-human kidney xenotransplant, Nature Communications Volume, 15: 3140. https://doi.org/10.21203/rs.3.rs-2382345/v1 Porrett P., Orandi B., Kumar V., Houp J., Anderson D., Killian A., Hauptfeld-Dolejsek V., Martin D., Macedon S., Budd N., Stegner K., Dandro A., Kokkinaki M., Kuravi K., Reed R., Fatima H., Killian J., Baker G., Perry J., Wright E., Cheung M., Erman E., Kraebber K., Gamblin T., Guy L., George J., Ayares D., and Locke J., 2022, First clinical‐grade porcine kidney xenotransplant using a human decedent model, American Journal of Transplantation, 22(4): 1037-1053. https://doi.org/10.1111/ajt.16930 PMid:35049121 Reichart B., Längin M., Radan J., Mokelke M., Buttgereit I., Ying J., Fresch A., Mayr T., Issl L., Buchholz S., Michel S., Ellgass R., Mihalj M., Egerer S., Baehr A., Kessler B., Kemter E., Kurome M., Zakhartchenko V., Steen S., Sjöberg T., Paskevicius A., Krüger L., Fiebig U., Denner J., Godehardt A., Tönjes R., Milusev A., Rieben R., Sfriso R., Walz C., Kirchner T., Ayares D., Lampe K., Schönmann U., Hagl C., Wolf E., Klymiuk N., Abicht J., and Brenner P., 2020, Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation?, The Journal of Heart and Lung Transplantation: the Official Publication of the International Society for Heart Transplantation, 39(8): 751-757. https://doi.org/10.1016/j.healun.2020.05.004 PMid:32527674 Ross M., Coates P., and Coates P., 2018, Using CRISPR to inactivate endogenous retroviruses in pigs: an important step toward safe xenotransplantation? Kidney international, 93(1): 4-6. https://doi.org/10.1016/j.kint.2017.11.004 PMid:29198467 Ryczek, N., Hryhorowicz, M., Zeyland, J., Lipinski, D., and Słomski, R, 2021, CRISPR/Cas Technology in pig-to-human xenotransplantation research, International Journal of Molecular Sciences, 22(6): 3196. https://doi.org/10.3390/ijms22063196 PMid:33801123 PMCid:PMC8004187 Singh A., Chan J., DiChiacchio L., Hardy N., Corcoran P., Lewis B., Thomas M., Burke A., Ayares D., Horvath K., and Mohiuddin M., 2018, Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs, Xenotransplantation, 26(2): e12465. https://doi.org/10.1111/xen.12465 PMid:30290025 PMCid:PMC6450784 Tanihara F., Hirata M., Nguyen N., Sawamoto O., Kikuchi T., and Otoi T., 2021, One-step generation of multiple gene-edited pigs by electroporation of the CRISPR/Cas9 system into zygotes to reduce xenoantigen biosynthesis, International Journal of Molecular Sciences, 22(5): 2249. https://doi.org/10.3390/ijms22052249 PMid:33668187 PMCid:PMC7956194 Tatapudi V., and Griesemer A., 2022, Physiologic considerations of pig-to-human kidney xenotransplantation, Current Opinion in Nephrology and Hypertension, 32: 193-198. https://doi.org/10.1097/MNH.0000000000000858 PMid:36683545 Wang R., Ruan M., Zhang R., Chen L., Li X., Fang B., Li C., Ren X., Liu J., Xiong Q., Zhang L., Jin Y., Li L., Li R., Wang Y., Yang H., and Dai Y., 2018, Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigs, Journal of Biomedical Research, 33(4): 235-243. https://doi.org/10.7555/JBR.32.20180018 PMid:30007952 PMCid:PMC6813527 Wu H., Lian M., and Lai L., 2023, Multiple gene modifications of pigs for overcoming obstacles of xenotransplantation, National Science Open, 2(5): 20230030. https://doi.org/10.1360/nso/20230030

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