International Journal of Molecular Medical Science, 2024, Vol.14, No.1, 69-79 http://medscipublisher.com/index.php/ijmms 69 Research Report Open Access The Role of Genomics in the Prevention of Cardiovascular Diseases WeiWang Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China Corresponding author email: 2741098603@qq.com International Journal of Molecular Medical Science, 2024, Vol.14, No.1 doi: 10.5376/ijmms.2024.14.0010 Received: 04 Mar., 2024 Accepted: 05 Apr., 2024 Published: 15 Apr., 2024 Copyright © 2024 Wang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Wang W., 2024, The role of genomics in the prevention of cardiovascular diseases, International Journal of Molecular Medical Science, 14(1): 69-79 (doi: 10.5376/ijmms.2024.14.0010) Abstract With the rapid development of high-throughput sequencing technology and the continuous progress of data analysis methods, genomics provides new perspectives and tools for the prevention of cardiovascular diseases. This study elaborates on the important role and potential impact of genomics in the prevention of cardiovascular diseases. Research has found that genomics not only helps guide drug selection and dosage adjustment, but also provides guidance for lifestyle interventions, thereby helping individuals reduce the risk of cardiovascular disease. By conducting in-depth research on the association between genes and cardiovascular disease, it is possible to accurately identify high-risk individuals and develop targeted prevention strategies. However, the application of genomics also faces ethical, privacy, technological, and legal challenges. In the future, with the continuous innovation of technology and the reduction of costs, genomics is expected to play a greater role in the prevention of cardiovascular diseases and make important contributions to human health. Keywords Genomics; Cardiovascular disease; Prevention; Risk assessment; Personalized drug selection Cardiovascular diseases, including coronary heart disease, stroke, hypertension, etc., have become a global health issue. With the aggravation of population aging, the change of lifestyle and the impact of environmental factors, the incidence rate and mortality of cardiovascular diseases are rising. According to the latest data from the World Health Organization (WHO), cardiovascular disease causes nearly 18 million deaths annually, accounting for more than one-third of the total global deaths (Roth et al., 2020). In addition, cardiovascular disease also brings enormous economic burden to patients and society, including medical expenses, loss of productivity, and decreased quality of life. In the face of this severe situation, preventing the occurrence of cardiovascular diseases has become a crucial task. Traditional cardiovascular disease prevention strategies mainly focus on lifestyle adjustment, control of risk factors (such as hypertension, hyperlipidemia, diabetes, etc.), and early screening and intervention (Becheva et al., 2023). However, these methods vary significantly among individuals, and some individuals may still develop cardiovascular disease despite following a healthy lifestyle. This indicates that in addition to traditional risk factors, there are other unknown genetic and environmental factors that affect the occurrence of cardiovascular disease. In order to gain a deeper understanding of the pathogenesis of cardiovascular disease and explore more precise and personalized prevention strategies, genomics research is particularly important. Genomics is a science that studies the structure, function, and evolution of the genome of living organisms. It utilizes advanced technologies such as high-throughput sequencing and bioinformatics analysis to comprehensively analyze the genetic information of the human genome (Pérez-Losada et al., 2020), revealing genetic variations and mechanisms related to cardiovascular diseases. Abraham et al. (2021) found through genomics research that using genomics can more accurately predict an individual's risk of cardiovascular disease, providing scientific basis for developing personalized prevention and treatment plans. The purpose of this study is to review the role of genomics in the prevention of cardiovascular disease, explain the importance of genomics in the research of cardiovascular disease by introducing the global status and impact of cardiovascular disease, and deeply discuss the application and challenges of genomics in the prevention of cardiovascular disease, hoping to provide useful reference and enlightenment for researchers and relevant
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