International Journal of Molecular Medical Science, 2024, Vol.14, No.1, 56-60 http://medscipublisher.com/index.php/ijmms 57 in Vero E6 cells was evaluated. Moreover, the EC50 values for FlipGFP PLpro were tested using 293T cells transfected with PLpro and FlipGFP. The antiviral activity (EC50) of these compounds against SARS-CoV-2 was assessed in Caco-2 cell lines expressing hACE2 and hTMPRSS2. The figure also provides data on the half-life (T1/2) of PLpro inhibitors in mouse liver microsomes, with all data presented as the mean ± standard deviation of three technical replicates. Figure 1 X-ray crystal structure of the covalent inhibitor Jun11313 with SARS-CoV-2 PLpro and structure-based design of biarylphenyl SARS-CoV-2PLpro inhibitors Figure 2 Representative biarylbenzamide series of SARS-CoV-2 PLpro inhibitors
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