International Journal of Clinical Case Reports, 2025, Vol.15, No.6, 259-270 http://medscipublisher.com/index.php/ijccr 265 At the same time, integrating biomarker results with multi-faceted neurological monitoring (including clinical examinations, neuroimaging, and electrophysiological tests) can form a comprehensive brain protection plan. Multidisciplinary teams can promptly enhance or weaken intervention measures based on the dynamic changes of biomarkers, making nursing more in line with the changes in patients' conditions. By integrating nursing measures with real-time molecular signals of brain injury, emergency department teams can more effectively reduce secondary injuries and increase the probability of good neurological recovery in patients (Perkins et al., 2021; Hoiland et al., 2022; Sandroni et al., 2023). 5.3 Biomarker-guided individualized care The use of biomarkers has led to the development of personalized care models, and treatment measures can also be formulated in combination with the actual risks and changes in the condition of each patient. For instance, if a patient's biomarker levels remain persistently low or gradually decline, the intensity of intensive monitoring can be appropriately reduced, and the early activity levels and care intensity can be gradually lowered. If these indicators continue to rise or remain at a high level, patients may require closer observation, more frequent neurological examinations, and continuous neuroprotective measures (Moseby-Knappe et al., 2021; Fink et al., 2022; Kaminoska et al., 2025). This personalized plan not only rationally allocates resources but also ensures that high-risk patients receive priority attention and treatment, helping them recover their health as much as possible. Whether it is children or adult patients, biomarker-guided nursing can provide an objective basis for doctor-patient communication, help family members better understand the prognosis and nursing goals, and conduct more targeted communication (Fink et al., 2022). With the increasing evidence of the prognostic value of biomarkers, systematically incorporating it into the standard nursing process is expected to further improve the accuracy and timeliness of post-cardiopulmonary resuscitation care in the emergency department, ultimately improving the recovery of patients and enhancing the utilization efficiency of medical resources (Moseby-Knappe et al., 2021; Hoiland et al., 2022). 6 Collaboration and Management of Biomarker Monitoring 6.1 Multi-disciplinary collaborative monitoring model Molecular monitoring of brain injury markers in the emergency department (ED) requires the joint efforts of multiple disciplines. Emergency department doctors, laboratory department, radiology department and nursing team should all be involved to ensure accurate sample collection, rapid analysis and correct result interpretation (Torrecilla et al., 2025). Both multicenter studies and expert consensus emphasize that processes should be unified and decisions should be made through consultation. This enables different hospitals to maintain consistent methods of using biomarkers and reduces differences in patient treatment. Regular interdisciplinary discussions and smooth communication can solve the problem of inconsistent results, continuously optimize the treatment process, and ensure that the quality of care does not decline. The cooperation also covers research and quality improvement work. The joint design and evaluation of biomarker usage protocols by multiple disciplines can make the methods more standardized and enable the research results to be applied to actual treatment more quickly. For instance, by integrating the opinions of experts in emergency medicine, radiology and laboratory medicine, markers such as GFAP and UK-L1 can be better utilized to improve the diagnostic accuracy and resource utilization efficiency of the emergency department (Torrecilla et al., 2025), enabling monitoring to not only meet clinical needs but also keep up with the pace of new evidence and new technologies. 6.2 Information transmission and communication of biomarkers The test results of biomarkers are an important basis for guiding patient treatment and team communication. Timely acquisition of test data enables the identification of patients with a low risk of brain injury, thereby reducing unnecessary high-end imaging examinations or specialist consultations (Torrecilla et al., 2025; Ballesteros et al., 2025; Campagna et al., 2025). Conversely, if the marker levels increase significantly, it indicates that the patient may need to be transferred to a place with better medical conditions as soon as possible, or be evaluated by a neurologist to ensure that critically ill patients can receive appropriate treatment in a timely manner
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