International Journal of Clinical Case Reports, 2025, Vol.15, No.1, 24-33 http://medscipublisher.com/index.php/ijccr 31 excessive use may result in cumulative toxicity, particularly in vulnerable populations such as children and immunocompromised individuals. Precautionary measures include ensuring proper dilution before topical use to prevent skin sensitization and strictly avoiding oral administration without medical supervision. Clinical practitioners are advised to screen patients for allergies to related plants and other essential oils before prescribing Chrysanthemum-based therapies. Monitoring for signs of hypersensitivity reactions, such as skin eruptions or respiratory distress, is critical (Li et al., 2019). Additionally, while the essential oil demonstrates promising antibacterial and anti-inflammatory properties, practitioners must balance benefits with risks, particularly for long-term applications. Adherence to established aromatherapy protocols and continuous safety evaluations will further support its clinical integration (Zhang et al., 2023). 8 Future Research Directions and Technological Innovations 8.1 Development of new extraction technologies: green, efficient, and sustainable The development of new extraction technologies for essential oils from Hangbai Chrysanthemum is crucial for enhancing efficiency and sustainability. Current methods, such as ultrasonic treatment and Soxhlet backflow extraction, have shown promise in increasing extraction rates and reducing costs, making them suitable for large-scale production (Zhang et al., 2017). However, there is a need to explore more innovative and non-conventional techniques that can further improve the quality and yield of essential oils while minimizing environmental impact. Techniques such as those reviewed in recent studies emphasize the importance of maintaining the integrity of essential components, reducing chemical risks, and shortening extraction times, all of which contribute to eco-friendly practices (Murti et al., 2023). Future research should focus on integrating these innovative methods with existing technologies to create hybrid systems that maximize the benefits of each approach. This could involve the use of advanced bioinformatics and molecular docking strategies to better understand the chemical profiles and optimize extraction processes (Yang et al., 2022). By doing so, researchers can ensure that the extraction of essential oils from Hangbai Chrysanthemum is not only efficient but also aligns with sustainable development goals. 8.2 Research and development of essential oil composite formulations The formulation of essential oil composites presents a promising area for research and development, particularly in enhancing the bioactivity and therapeutic potential of Hangbai Chrysanthemum oils. Studies have shown that different extraction methods can significantly affect the chemical composition and bioactivity of chrysanthemum extracts, suggesting that composite formulations could be tailored to enhance specific properties such as antioxidant and antibacterial activities (Zhang et al., 2020; Gao et al., 2024). For instance, combining extracts with high phenolic content with those rich in proteins or carbohydrates could create formulations with synergistic effects. Moreover, the exploration of essential oil composites could lead to the development of new applications in the pharmaceutical and food industries. Essential oils have been recognized for their potential as natural preservatives and therapeutic agents, and composite formulations could enhance these properties, offering more effective and versatile products (Murti et al., 2023). Future research should aim to identify optimal combinations of essential oil components and assess their efficacy through rigorous clinical testing. 8.3 The prospects for clinical research and interdisciplinary collaboration The prospects for clinical research on Hangbai Chrysanthemum essential oils are vast, with potential applications in various medical fields. Essential oils have been identified as having significant antioxidant and anti-glycation properties, which could be beneficial in managing conditions related to oxidative stress and glycation (Gao et al., 2024). Clinical trials are needed to validate these effects and explore the therapeutic potential of these oils in treating diseases such as diabetes and cardiovascular disorders.
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