International Journal of Clinical Case Reports, 2025, Vol.15, No.1, 1-11 http://medscipublisher.com/index.php/ijccr 9 Despite the potential benefits, current research on the Five Elements dietary adjustments is limited by the lack of large-scale, high-quality clinical trials and standardized methods for determining elemental constitutions. Most existing studies are observational or based on small sample sizes, which restricts the generalizability of their findings. Future research should focus on conducting rigorous clinical trials to validate the efficacy of the Five Elements dietary interventions and developing standardized diagnostic tools for assessing elemental constitutions. Additionally, exploring the molecular mechanisms behind the Five Elements foods and their bioactive compounds would further strengthen the scientific foundation of this dietary approach. In the context of public health, the integration of Five Elements dietary principles into mainstream healthcare has significant potential. By promoting a balanced and holistic approach to diet, which aligns with both modern nutritional science and traditional practices, the Five Elements Theory could play a key role in preventing and managing widespread metabolic diseases. Public health strategies could incorporate educational campaigns and collaborative programs between TCM practitioners and nutritionists to promote the benefits of personalized dietary adjustments. This fusion of traditional and modern medicine could offer a culturally adaptable and accessible approach to improving metabolic health on a global scale. Acknowledgments Thank you to the anonymous peer review for providing targeted revision suggestions for the manuscript. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Assmann G., Buono P., Daniele A., Della Valle E., Farinaro E., Ferns G., Krogh V., Kromhout D., Masana L., Merino J., Misciagna G., Panico S., Riccardi G., Rivellese A.A., Rozza F., Salvatore F., Salvatore V., Stranges S., Trevisan M., Trimarco B., and Vetrani C., 2014, Functional foods and cardiometabolic diseases, international task force for prevention of cardiometabolic diseases, Nutrition, Metabolism and Cardiovascular Diseases, 24(12): 1272-1300. https://doi.org/10.1016/J.NUMECD.2014.10.010 Bin C., 2007, The discuss on Chinese medical science theory about correlation of five viscera, Journal of Hubei Institute for Nationalities, 10: 223. Brown L., Caligiuri S., Brown D., and Pierce G., 2018, Clinical trials using functional foods provide unique challenges, Journal of Functional Foods, 45: 233-238. https://doi.org/10.1016/J.JFF.2018.01.024 Cai L., Yin J., Ma X, Mo Y., Li C., Lu W., Bao Y., Zhou J., and Jia W., 2021, Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial, Frontiers of Medicine, 15: 460-471. https://doi.org/10.1007/s11684-021-0861-6 Chen M.Y., and Yu S.Y., 2024, The classification study and categorization of medicinal properties in traditional Chinese medicine, International Journal of Clinical Case Reports, 14(1): 14-22. https://doi.org/ijccr.2024.14.0002 Chen Y., Liu T., Teia F., and Xie M., 2023, Exploring the underlying mechanisms of obesity and diabetes and the potential of Traditional Chinese Medicine: an overview of the literature, Frontiers in Endocrinology, 14: 1218880. https://doi.org/10.3389/fendo.2023.1218880 Chen L., Chen X.B., Wang J.K., Zhou K., Gong W.B., Su Q., Zhang Y., Gu Y.J., Tang K.W., and Wang H., 2013, WANG Hui's exploration on various stages of physiology and pathology of five elements constitutions, Chinese Archives of Traditional Chinese Medicine, 31(10): 2153-2155. https://doi.org/10.13193/j.issn.1673-7717.2013.10.032 Chesla C., Chun K., and Kwan C., 2009, Cultural and family challenges to managing type 2 diabetes in immigrant Chinese Americans, Diabetes Care, 32: 1812-1816. https://doi.org/10.2U337/dc09-0278. Crowe K., and Francis C., 2013, Position of the academy of nutrition and dietetics: functional foods, Journal of the Academy of Nutrition and Dietetics, 113(8): 1096-103. https://doi.org/10.1016/j.jand.2013.06.002 Fallows E., 2023, Lifestyle medicine: a cultural shift in medicine that can drive integration of care, Future Healthcare Journal, 10: 226-231. https://doi.org/10.7861/fhj.2023-0094 Fong S., 2022, Modified Traditional Chinese Medicine formula: is it still effective?, Borneo Journal of Medical Sciences, 16(3): 1-2. https://doi.org/10.51200/bjms.v16i3.3887 Gao Y., 2017, Traditional Chinese medical nutrition and western nutrition, Journal of Analytical & Pharmaceutical Research, 4(2): 45-47. https://doi.org/10.15406/JAPLR.2017.04.00098.
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