International Journal of Clinical Case Reports 2024, Vol.14, No.6, 327-338 http://medscipublisher.com/index.php/ijccr 335 and its complications (Park et al., 2006; Do et al., 2018). The use of advanced extraction and purification techniques, combined with modern pharmacological research, can facilitate the creation of standardized, high-efficacy antidiabetic products derived fromE. ulmoides (Zhang et al., 2015; Niu et al., 2016). In conclusion, while there are significant challenges in the standardization and quality control of Eucommia ulmoides extracts, future research in pharmacogenomics and the development of novel formulations hold promising potential for enhancing the antidiabetic applications of this traditional medicinal plant. 9 Concluding Remarks Eucommia ulmoides, a traditional Chinese medicinal plant, has demonstrated significant antidiabetic potential through various phytochemicals, particularly iridoid glycosides, flavonoids, and phenolic compounds. Studies have shown that extracts from different parts of the plant, including seeds, leaves, and bark, exhibit strong antioxidant, anti-inflammatory, and glycation inhibitory activities, which are crucial in managing diabetes and its complications. For instance, the ethanol extract of E. ulmoides leaves has been found to inhibit disaccharidase and glucose transport in Caco-2 cells, indicating its potential to control postprandial blood glucose levels. Additionally, long-term administration of E. ulmoides leaf extract has been shown to ameliorate insulin resistance and abnormal perivascular innervation in fructose-drinking rats, further supporting its antidiabetic efficacy. The phytochemicals isolated fromEucommia ulmoides, such as iridoid glycosides and flavonoids, have shown promising results in preclinical studies, suggesting their potential use in clinical settings for the management of diabetes and its complications. The antioxidant properties of these compounds can help mitigate oxidative stress, a major factor in the progression of diabetes. Moreover, the ability of E. ulmoides extracts to inhibit carbohydrate-degrading enzymes and glucose transporters highlights their potential as natural alternatives to conventional antidiabetic drugs like acarbose. Clinical trials focusing on the efficacy, safety, and optimal dosing of E. ulmoides extracts and their active compounds are warranted to establish their therapeutic potential in diabetic patients. The future of antidiabetic research in Eucommia ulmoides looks promising, given the extensive pharmacological activities demonstrated by its phytochemicals. Further research should focus on elucidating the molecular mechanisms underlying the antidiabetic effects of E. ulmoides compounds, as well as their interactions with other antidiabetic agents. Additionally, the development of standardized extracts and formulations will be crucial for ensuring consistent therapeutic outcomes. Collaborative efforts between researchers, clinicians, and pharmaceutical companies can pave the way for the integration of E. ulmoides-based therapies into mainstream diabetes management, offering a natural and effective alternative to synthetic drugs. Funding This work was supported by the Guizhou Academy of Agricultural Sciences Talent Special Project (No. 2023-02, No.2024-02), National Natural Science Foundation of China [No. 31660076, 31360272]，Talent Base for Germplasm Resources Utilization and Innovation of Characteristic Plant in Guizhou (RCJD2018-14). Acknowledgments Thank you to the anonymous peer reviewers for their feedback on the initial draft of this manuscript. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Abdullah A., Biswas P., Sahabuddin M., Mubasharah A., Khan D., Hossain A., Roy T., Rafi N., Dey D., Hasan M., Bibi S., Moustafa M., Shati A., Hassan H., and Garg R., 2023, Molecular dynamics simulation and pharmacoinformatic integrated analysis of bioactive phytochemicals from Azadirachta indica (Neem) to treat diabetes mellitus, Journal of Chemistry, (1): 4170703. https://doi.org/10.1155/2023/4170703
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