International Journal of Clinical Case Reports 2024, Vol.14, No.6, 312-326 http://medscipublisher.com/index.php/ijccr Compared with the Low-dose group, there is a difference p 0.05. @: Compared with the Medium-dose group, there is a difference p 0.05 (Adopted from Hu et al., 2023) 6.2 Immunomodulatory effects of Xanthoceras Sorbifolia oil Xanthoceras sorbifolia oil also exhibits significant immunomodulatory effects, which can be attributed to its rich content of phenolic compounds. These compounds have been shown to modulate immune responses and reduce inflammation, making the oil a potential natural immunomodulator. Studies have shown that phenolic acid-rich compounds extracted from Xanthoceras sorbifolia shells can significantly reduce the severity of experimental autoimmune encephalomyelitis (EAE). The extract alleviated neuroinflammation and CNS demyelination by reducing the infiltration of pathogenic immune cells into the central nervous system (CNS) and inhibiting the production of pro-inflammatory cytokines (Zhao et al., 2018). This finding suggests that Xanthoceras sorbifolia oil may be beneficial in treating autoimmune and inflammatory diseases (Wang and Jin, 2024). The immunomodulatory properties of X. sorbifolia are supported by its traditional use in Chinese medicine for various health conditions. Modern pharmacological studies have confirmed its ability to modulate immune responses, providing a scientific basis for its traditional applications (Chen et al., 2021). These findings underscore the potential of X. sorbifolia oil as a natural immunomodulatory agent. 6.3 Applications in skin care Xanthoceras sorbifolia oil has promising applications in skin care due to its antioxidant and anti-inflammatory properties. The oil is rich in monounsaturated fatty acids, particularly oleic acid and nervonic acid, which are beneficial for skin health. The antioxidant activity of X. sorbifolia oil helps protect the skin from oxidative stress and environmental damage. Studies have shown that the oil possesses significant DPPH radical-scavenging activity, indicating its potential to neutralize free radicals and prevent oxidative damage to the skin (Zhang et al., 2010; Zheng et al., 2022). This makes it a valuable ingredient in anti-aging and protective skin care formulations. Additionally, the anti-inflammatory properties of X. sorbifolia oil can help soothe irritated skin and reduce inflammation. The phenolic compounds in the oil have been shown to inhibit the production of pro-inflammatory cytokines, which can help manage skin conditions such as eczema and psoriasis (Zang et al., 2021). The oil's ability to enhance skin barrier function and promote healing further supports its use in skin care products. Xanthoceras sorbifolia oil offers a range of health benefits beyond its well-known antioxidative and cardiovascular protective effects. Its neuroprotective, immunomodulatory, and skin care applications make it a versatile and valuable natural product with significant therapeutic potential. Further research and development are warranted to fully explore and harness these benefits for clinical and commercial use. 7 Safety and Toxicological Studies of Xanthoceras Sorbifolia Oil 7.1 Toxicological study results The safety and toxicological characteristics of Xanthoceras sorbifolia oil have been the subject of multiple studies, mainly focusing on its chemical composition and potential health benefits. The oil is rich in unsaturated fatty acids, particularly oleic acid and linoleic acid, which are well-known for their beneficial effects on cardiovascular health (Zhang et al., 2010; Gu et al., 2019). However, comprehensive studies on the safety and toxicological effects of long-term consumption of Xanthoceras sorbifolia oil are still relatively limited, indicating a need for further research in this area in the future. In vitro studies have demonstrated that the oil possesses significant antioxidant activity, which is indicative of its potential to mitigate oxidative stress-related damage in biological systems (Zhang et al., 2010; Zhao et al., 2018). The antioxidant properties are largely attributed to the high content of phenolic compounds and tocopherol 320 s
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