IJCCR_2024v14n5

International Journal of Clinical Case Reports 2024, Vol.14, No.5, 262-275 http://medscipublisher.com/index.php/ijccr 274 Ishimitsu A., Tojo A., Satonaka H., and Ishimitsu T., 2021, Eucommia ulmoides (Tochu) and its extract geniposidic acid reduced blood pressure and improved renal hemodynamics, Biomed Pharmacother., 141: 111901. https://doi.org/10.1016/j.biopha.2021.111901 PMID: 34328117 Kannel W., 1974, Role of blood pressure in cardiovascular morbidity and mortality, Progress in Cardiovascular Diseases, 17(1): 5-24. https://doi.org/10.1016/0033-0620(74)90034-6 PMID: 4276031 Kita S., Tagashira H., Kita T., and Iwamoto T., 2019, Eucommia ulmoides Oliver leaf extract improves the development of hypoxia-induced pulmonary arterial hypertension, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92(1): 60. https://doi.org/10.1254/JPSSUPPL.92.0_1-P-060 Kwan C., Chen C., Deyama T., and Nishibe S., 2003, Endothelium-dependent vasorelaxant effects of the aqueous extracts of the Eucommia ulmoides Oliv, leaf and bark: implications on their antihypertensive action, Vascular Pharmacology, 40(5): 229-235. https://doi.org/10.1016/J.VPH.2003.09.001 PMID: 15259789 Kwan C., Zhang W., Deyama T., and Nishibe S., 2004, Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv, bark extract is mediated by NO and EDHF in small vessels, Naunyn-Schmiedeberg's Archives of Pharmacology, 369(2): 206-211. https://doi.org/10.1007/s00210-003-0822-4 PMID: 14673511 Kwan C., Zhang W., Deyama T., and Nishibe S., 2007, In vitro vascular effects of Eucommia ulmoides Oliv, International Symposium on Eucommia ulmoides, 1(1): 11-14. https://doi.org/10.3387/ISEU.1.11 Lang C., Liu Z., Taylor H., and Baker D., 2005, Effect of Eucommia ulmoides on systolic blood pressure in the spontaneous hypertensive rat, The American Journal of Chinese Medicine, 33(2): 215-230. https://doi.org/10.1142/S0192415X05002795 PMID: 15974481 Lee G., Lee H., choi M., Choi A., Shin T., and Chae H., 2018, Eucommia ulmoides leaf (EUL) extract enhances no production in ox-LDL-treated human endothelial cells, Biomed Pharmacother., 97, 1164-1172. https://doi.org/10.1016/j.biopha.2017.11.035 PMID: 29136955 Li Z., Gu J., Yan J., Wang J., Huang W., Tan Z., Zhou G., Chen Y., Zhou H., and Ouyang D., 2013, Hypertensive cardiac remodeling effects of lignan extracts fromEucommia ulmoides Oliv, bark--a famous traditional Chinese medicine, The American Journal of Chinese Medicine, 41(4): 801-881. https://doi.org/10.1142/S0192415X13500547 PMID: 23895153 Luo L., Wu W., Zhou Y., Yan J., Yang G., and Ouyang D., 2010, Antihypertensive effect of Eucommia ulmoides Oliv, extracts in spontaneously hypertensive rats, Journal of Ethnopharmacology, 129(2): 238-243. https://doi.org/10.1016/j.jep.2010.03.019 PMID: 20347950 Niu X., Xu D., Luo J., and Kong L., 2016, Main iridoid glycosides and HPLC/DAD-Q-TOF-MS/MS profile of glycosides from the antioxidant extract of Eucommia ulmoides Oliver seeds, Industrial Crops and Products, 79(4): 160-169. https://doi.org/ 10.1016/J.INDCROP.2015.11.027 Peng M., Tian S., Song Y., Li C., Miao M., Ren Z., and Li M., 2021, Effects of total flavonoids fromEucommia ulmoides Oliv, leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet, Journal of Ethnopharmacology, 273: 113947. https://doi.org/10.1016/j.jep.2021.113947 PMID: 33617969 Peng M., Wang Z., Peng S., Zhang M., Duan Y., Li F., Shi S., Yang Q., and Zhang C., 2019, Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets, PLoS ONE, 14(9): e0223002. https://doi.org/10.1371/journal.pone.0223002 PMID: 31557247 PMCID: PMC6762056 Qi Y., Yang X., Jiang Y., Shao L., Jiang L., and Yang C., 2020, Study of the mechanism underlying the antihypertensive effects of Eucommia ulmoides and tribulus terrestris based on an analysis of the intestinal microbiota and metabonomics, BioMed Research International, 2020: 4261485. https://doi.org/10.1155/2020/4261485 Tsukamoto S., Yamaguchi Y., Ueda T., Kajimoto O., Nakazawa Y., Nakagawa S., and Kajimoto Y., 2007, Hypotensive effects of beverages containing Eucommia leaf glycosides on high normotensive and mild hypertensive subjects, Int. Symp. Eucommia Ulmoides, 1(1): 47-54. https://doi.org/10.3387/iseu.1.47 Wang C., Tang L., He J., Li J., and Wang Y., 2019, Ethnobotany, phytochemistry and pharmacological properties of Eucommia ulmoides: a review, The American Journal of Chinese Medicine, 47(2): 259-300. https://doi.org/10.1142/ S0192415X19500137

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