International Journal of Clinical Case Reports 2024, Vol.14, No.5, 262-275 http://medscipublisher.com/index.php/ijccr 264 3 Mechanisms of Hypotensive Action 3.1 Gut microbiota regulation Eucommia ulmoides (EU) has been shown to significantly influence the diversity and composition of the gut microbiota. In a study involving high-salt diet and N(omega)-nitro-L-arginine methyl ester (L-NAME) induced hypertensive mice, administration of EU for six weeks resulted in a notable reduction in blood pressure and improvement in kidney injury. The study identified 40 significantly upregulated and 107 significantly downregulated amplicon sequence variants (ASVs) in the gut microbiota following EU treatm (Figure 1)ent. This indicates that EU can modulate the gut microbiota, which may contribute to its antihypertensive effects (Yan et al., 2022). Figure 1 EU influences gut microbiota diversity and composition in hypertensive mice subjected to a high-salt diet (HSD) and L-NAME treatment (Adopted from Yan et al., 2022) Image caption: (A) Shannon index, Faith’s PD, and Observed Features in the EU + HSD, HSD, and ND groups in week 13 and the EU+HSD and HSD groups in weeks 10 and 13. (B) Principal co-ordinates analysis of bacterial communities in the EU + HSD and HSD groups in week 10 and in the EU + HSD, HSD, and ND groups in week 13. PC1: principal component 1; PC2: principal component 2. (C) Relative abundances of dominant genera (> 0.03%) in the EU + HSD, HSD, and ND groups in week 13 (Adopted from Yan et al., 2022)
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