International Journal of Clinical Case Reports 2024, Vol.14, No.5, 242-252 http://medscipublisher.com/index.php/ijccr 250 immunotherapeutic strategies and personalized vaccines. Lastly, longitudinal studies that track the evolution of HPV variants over time in response to vaccination and therapeutic interventions are crucial for monitoring the effectiveness of these strategies and adapting them as needed. In conclusion, continued research on HPV16 and HPV18 variants is essential to fully understand their role in cervical cancer and to develop more effective diagnostic, therapeutic, and preventive strategies. By focusing on these key areas, we can improve patient outcomes and ultimately reduce the global burden of HPV-associated cancers. Acknowledgments I would like to thank two anonymous peer reviewers for their suggestions on my manuscript. Conflict of Interest Disclosure The author affirms that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Alfaro A.M.H., Juárez-Torres E., Medina-Martínez I., Mateos-Guerrero N., Bautista-Huerta M., Román-Bassaure E., Villegas-Sepúlveda N., and Berumen J., 2016, Different association of human papillomavirus 16 variants with early and late presentation of cervical cancer, PLoS ONE, 11(12): e0169315. https://doi.org/10.1371/journal.pone.0169315 PMID: 28036379 PMCID: PMC5201311 Badano I., Totaro M., Culasso A., Sanabria D.J., Schurr T., Balette I.C., Roisman A., Basiletti J., Picconi M.A., Campos R.H., and Liotta D.J., 2015, Genetic characterization and clinical implications of human papillomavirus type 16 (HPV16) variants from northeastern Argentina, Infection, Genetics and Evolution, 29: 103-109. https://doi.org/10.1016/j.meegid.2014.11.013 Bruyère D., Roncarati P., Lebeau A., Lerho T., Poulain F., Hendrick E., Pilard C., Reynders C., Ancion M., Luyckx M., Renard M., Jacob Y., Twizere J., Peiffer R., Peulen O., Delvenne P., Hubert P., McBride A., Gillet N., Masson M., and Herfs M., 2023, Human papillomavirus E6/E7 oncoproteins promote radiotherapy-mediated tumor suppression by globally hijacking host DNA damage repair, Theranostics, 13: 1130-1149. https://doi.org/10.7150/thno.78091 PMID: 36793865 PMCID: PMC9925306 Chen A., Gheit T., Franceschi S., Tommasino M., and Clifford G., 2014, Human papillomavirus 18 genetic variation and cervical cancer risk worldwide, Journal of Virology, 89: 10680-10687. https://doi.org/10.1128/JVI.01747-15 PMID: 26269181 PMCID: PMC4580183 Chopjitt P., Pientong C., Sunthamala N., Kongyingyoes B., Haonon O., Boonmars T., Kikawa S., Nakahara T., Kiyono T., and Ekalaksananan T., 2016, E6D25E, HPV16 Asian variant shows specific proteomic pattern correlating in cells transformation and suppressive innate immune response, Biochemical and Biophysical Research Communications, 478(1): 417-423. https://doi.org/10.1016/j.bbrc.2016.07.025 PMID: 27392712 Cornet I., Gheit T., Iannacone M., Vignat J., Sylla B., Mistro A., Franceschi S., Tommasino M., and Clifford G., 2012, HPV16 genetic variation and the development of cervical cancer worldwide, British Journal of Cancer, 108: 240-244. https://doi.org/10.1038/bjc.2012.508 PMID: 23169278 PMCID: PMC3553516 da Mata S., Ferreira J., Nicolás I., Esteves S., Esteves G., Lérias S., Silva F., Saco A., Cochicho D., Cunha M., Del Pino M., Ordi J., and Félix A., 2021, P16 and HPV genotype significance in HPV-associated cervical cancer-a large cohort of two tertiary referral centers, International Journal of Molecular Sciences, 22(5): 2294. https://doi.org/10.3390/ijms22052294 PMID: 33669021 PMCID: PMC7956391 Dai S., Yao Y., Yan Z., Zhou Z., Shi L., Wang X., Sun L., Zhang R., and Yao Y., 2018, The association of human papillomavirus type 16 E2 variations with cervical cancer in a Han Chinese population, Infection, Genetics and Evolution, 64: 241-248. https://doi.org/10.1016/j.meegid.2018.07.002 PMID: 30008422 Dust K., Carpenter M., Chen J., Grant C., McCorrister S., Westmacott G., and Severini A., 2022, Human papillomavirus 16 E6 and E7 oncoproteins alter the abundance of proteins associated with DNA damage response, Immune Signaling and Epidermal Differentiation, Viruses, 14(8): 1764. https://doi.org/10.3390/v14081764 PMID: 36016386 PMCID: PMC9415472
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