International Journal of Clinical Case Reports 2024, Vol.14, No.2, 87-93 http://medscipublisher.com/index.php/ijccr 87 Research Report Open Access Analysis of the Correlation between Drug Toxicity and Specific Gene Mutations LiqinZhou Zhuji Fourth People's Hospital, Zhuji, 311800, Zhejiang, China Corresponding email: 1768126628@qq.com International Journal of Clinical Case Reports 2024, Vol.14, No.2 doi: 10.5376/ijccr.2024.14.0011 Received: 05 Apr., 2024 Accepted: 07 May, 2024 Published: 18 May, 2024 Copyright © 2024 Zhou, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Zhou L.Q., 2024, Analysis of the correlation between drug toxicity and specific gene mutations, International Journal of Clinical Case Reports, 14(2): 87-93 (doi: 10.5376/ijccr.2024.14.0011) Abstract With the rise of the concept of personalized medicine, individual differences in drug response in medication have increasingly attracted widespread attention. Drug toxicity is a significant adverse reaction in drug therapy, resulting from the interaction of multiple factors, including the nature of the drug itself, the individual's physiological condition, and genetic variations. The mechanism of drug toxicity involves multiple levels. As a crucial factor, genetic variation may directly influence the activity of drug-metabolizing enzymes, thereby significantly affecting the metabolic rate and clearance of drugs. Genes such as those in the CYP family and transporter families play pivotal roles in drug metabolism pathways. Genetic variations may lead to alterations in the functions of these critical genes, impacting the metabolism and distribution of drugs within the body. This study, through a systematic literature study and comprehensive analysis, delves deeply into the close association between drug toxicity and specific genetic variations. The aim is to better predict patients' responses to drugs and provide a reference basis for formulating more precise treatment plans. Keywords Drug toxicity; Genetic variation; Drug metabolism; Clinical practice; Personalized medicine The individual differences in drug therapy have always been a concern in medical research and clinical practice. Under the same treatment conditions, there may be significant differences in the response of different individuals to drugs. This not only affects the therapeutic effect, but may also lead to adverse reactions and drug toxicity. One of the fundamental reasons for this individual difference is genetic variation. With the completion of the Human Genome Project and the development of high-throughput sequencing technology, people have gained a deeper understanding of the association between genes and drug responses. Drug toxicity, as a major side effect of drug therapy, involves multiple mechanisms, including drug metabolism, transport, target selectivity, and immune system response. In previous studies, it has been found that the toxic reactions caused by different drugs may have similar manifestations, but their underlying mechanisms are different. Therefore, it is of great significance for people to deeply explore the types and mechanisms of drug toxicity, understand the pathways of drug action in the body, avoid or reduce the occurrence of drug toxicity, and develop more personalized treatment plans for patients (Li et al., 2021). In the process of drug therapy, drug metabolism and transport are key factors affecting drug concentration and efficacy. In this context, mutations in specific genes can directly affect the metabolic rate, clearance rate, and sensitivity of drugs. Key genes such as the CYP family and transporter family play crucial roles in drug metabolism pathways. People's in-depth study of the functions and variations of these genes is of great clinical significance in predicting the metabolic efficiency of individuals towards specific drugs, thereby providing more accurate guidance for personalized medication (Fu et al., 2021). In clinical practice, personalized therapy has achieved significant results in some fields. Targeted drugs and immunotherapy in cancer treatment are one of the successful cases of personalized therapy. This study provides a comprehensive study of the types and mechanisms of toxic reactions caused by different drugs, delves into the relationship between specific genetic variations and drug metabolism, analyzes the application of personalized therapy in clinical practice, and aims to reveal the precise relationship between individual genotypes and drug effects, providing more accurate guidance for personalized medication.
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