International Journal of Clinical Case Reports 2024, Vol.14, No.1, 55-62 http://medscipublisher.com/index.php/ijccr 62 sequencing will be more widely applied in clinical practice, contributing to better-tailored treatment plans. Individualized drug therapy will become a more standard practice, allowing physicians to select and adjust drug dosages more effectively to meet the specific needs of patients and enhance treatment outcomes. The prospects of research on drug metabolizing enzyme gene polymorphism are vast, offering new avenues for improved healthcare and more effective treatments. Future studies and clinical practices will continue to delve into the complex mechanisms of drug metabolizing enzyme gene polymorphism, providing further opportunities for personalized medicine. However, it is essential to ensure the feasibility and sustainability of personalized healthcare simultaneously. References Cagin L.H., Katharina K., Inger J., Lovsletten S.R., Marin J., Espen M., and Magnus I.S., 2022, The polymorphic nuclear factor NFIB regulates hepatic CYP2D6 expression and influences risperidone metabolism in psychiatric patients, Clin. Pharmacol. Ther., 111(5): 1165-1174. https://doi.org/10.1002/cpt.2571 Dev B.B., Ranjeet K., Latha T.K., Harendra S., Kumar T.G., and Tusha S., 2019, Effect of Environmental Exposure and Pharmacogenomics on Drug Metabolism, Curr. Drug. Metab., 20(14): 1103-1113. https://doi.org/10.2174/1389200221666200110153304 Gao P., Jia X.J., Chu L.J., Li D.Z., Sun X., and Zhang Y., 2023, COMT gene polymorphism is associated with treatment response in panic disorder, Zhongguo Shenjing Jingshen Jibing Zazhi (Chinese Journal of Nervous and Mental Diseases), 49(3): 151-154. Li X.L., Duan X.R., Zhang H., Ding M.C., Wang Y.B., Yang Y.L., Yao W., Zhou X.S., and Wang W., 2021, Genetic polymorphisms of metabolic enzyme genes associated with leukocyte mitochondrial DNA copy number in PAHs exposure workers, Cancer Reports, 4(4): e1361. https://doi.org/10.1002/cnr2.1361 Ping J.J., Zhang J., Gao Y.S., Wan J., and Du B.G., 2022, Study on distribution of CYP2D6 gene polymorphism and metabolic phenotype in patients with refractory mental illness in Zhongshan area, Guoji Jianyan Yixue Zazhi (International Journal of Laboratory Medicine), 43(4): 445-450. Pe P., Zhong X.B., and Ku W.W., 2020, Histone Methyltransferase G9a regulates expression of nuclear receptors and cytochrome P450 enzymes in HepaRG cells at basal level and in fatty acid induced steatosis, Drug Metab. Dispos., 48(12): 1321-1329. https://doi.org/10.1124/dmd.120.000195 Vyhlidalova B., Poulikova K., Bartonkova I., Krasulova K., Vanco J., Travnicek Z., Mani S., and Dvorak Z., 2019, Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells, Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research, 313: 66-76. https://doi.org/10.1016/j.toxlet.2019.06.004 Xu X.C., Liu Y.H., Ta N., Li Y.S., and Zhang D.W., 2018, Study on CYP2C19 gene polymorphism and its metabolism-related drugs, Zhongguo Xiandai Yisheng (Modern Chinese Doctor), 56(1): 165-168. Xu Z.Y., Guo H.L., Hu Y.H., Chen F., Xu J., and Tian M., 2022, An updated review on isoniazid-induced hepatotoxicity and it's influencing factors, Zhongguo Xinyao Zazhi (Chinese Journal of New Drugs), 31(22): 2251-2256. Zhang Z., and Cai W.M., 2018, Research progress on the effect of UGT1A1 gene polymorphisms on drug metabo-lism and clinical efficacy, Yaoxue Sshijian Zazhi (Journal of Pharmaceutical Practice), 36(6): 488-492.
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