IJCCR_2024v14n1

International Journal of Clinical Case Reports 2024, Vol.14, No.1, 31-39 http://medscipublisher.com/index.php/ijccr 38 practical value for understanding the pathogenesis of intestinal diseases and developing new disease diagnosis and treatment strategies. Feng et al. (2018) discussed the intestinal The interaction between the gut microbiome and physical organs and systems, including the brain, lungs, liver, bones, cardiovascular system, etc., highlights the microbiota's role as a primary signal connecting the gut through metabolites such as short-chain fatty acids such as butyrate. Microbiome and physiological function. Sommer et al. (2017) discussed how the resilience of the gut microbiome affects health and disease, including their critical role in maintaining intestinal homeostasis and preventing inflammatory bowel disease and metabolic diseases. Looking to the future, as research continues to deepen and technology advances, it is believed that intestinal microbiome research will bring more new understandings and discoveries about intestinal health and diseases. These research results will also provide new ideas and methods for human health maintenance and disease prevention and treatment. Reference Anand S., and Mande S.S., 2018, Diet, Microbiota and gut-lung connection, Frontiers in Microbiology, 9: 2147. https://doi.org/10.3389/fmicb.2018.02147 Bäumler A.J., and Sperandio V., 2016, Interactions between the microbiota and pathogenic bacteria in the gut, Nature, 535(7610): 85-93. https://doi.org/10.1038/nature18849 Belkaid Y, Hand TW., 2014, Role of the microbiota in immunity and inflammation, Cell, 157(1): 121-41. https://doi.org/10.1016/j.cell.2014.03.011 Blekhman R., Goodrich J., Huang K., Sun Q., Bukowski R., Bell J., Spector T., Keinan A., Ley R., Gevers D., and Clark A., 2015, Host genetic variation impacts microbiome composition across human body sites, Genome Biology, 16(1): 191. https://doi.org/10.1186/s13059-015-0759-1 Boulangé C., Neves A. L., Chilloux J., Nicholson J.K., and Dumas M.E., 2016, Impact of the gut microbiota on inflammation, obesity, and metabolic disease, Genome Medicine, 8: 42. https://doi.org/10.1186/s13073-016-0303-2 Cai X.Y., Liu Y.C., Xie Z.H., Chen Y.L., and Liu R.J., 2020, Research advances in mutualistic symbiotic microbes diversities. Microbiology China, 47(11): 3899-3917. Cani P.D., 2018, Human gut microbiome: hopes, threats and promises, Gut, 67: 1716-1725. https://doi.org/10.1136/gutjnl-2018-316723 Chassaing B., Koren O., Goodrich J.K., Poole A.C., Srinivasan S., Ley R.E., and Gewirtz A.T., 2015, Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome, Nature, 519: 92-96. https://doi.org/10.1038/nature14232 Conlon M., and Bird A., 2014, The impact of diet and lifestyle on gut microbiota and human health, Nutrients, 7: 17-44. https://doi.org/10.3390/nu7010017 Feng Q., Chen W., and Wang Y., 2018, Gut microbiota: An integral moderator in health and disease, Frontiers in Microbiology, 9: 151. https://doi.org/10.3389/fmicb.2018.00151 Franzosa E.A., Sirota-Madi A., Avila-Pacheco J., Fornelos N., Haiser H.J., Reinker S., Vatanen T., Hall A.B., Mallick H., McIver L.J., Sauk J.S., Wilson R.G., Stevens B.W., Scott J.M., Pierce K., Deik A.A., Bullock K., Imhann F., Porter J.A., Zhernakova A., Fu J., Weersma R.K., Wijmenga C., Clish C.B., Vlamakis H., Huttenhower C., Xavier R.J., 2019, Gut microbiome structure and metabolic activity in inflammatory bowel disease, Nat Microbiol, 4(2): 293-305. https://doi.org/10.1038/s41564-018-0306-4 Gu Y.Y., Zhong H.Z., and Li J.H., 2019, Gut microbiota and metabolic diseases, Ziran Zazhi (Chinese Journal of Nature), 41(6): 431-438. Gupta V., Paul S., and Dutta C., 2017, Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity, frontiers in microbiology, 8: 1162. https://doi.org/10.3389/fmicb.2017.01162 Hills R., Pontefract B., Mishcon H., Black C., Sutton S., and Theberge C., 2019, Gut microbiome: Profound implications for diet and disease, Nutrients, 11(7): 1613. https://doi.org/10.3390/nu11071613 Hua X., Song L., Yu G., Vogtmann E., Goedert J., Abnet C., Landi M., and Shi J., 2015, Microbiomegwas: a tool for identifying host genetic variants associated with microbiome composition, Genes, 13(7): 1224. https://doi.org/10.3390/genes13071224 Jackson D. N., and Theiss A. L., 2019, Gut bacteria signaling to mitochondria in intestinal inflammation and cancer, Gut Microbes, 11(3): 285-304. https://doi.org/10.1080/19490976.2019.1592421

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